Systematic review and meta-analysis of global prevalence of neurotoxic and hemotoxic snakebite envenomation
Copyright © Authors 2022; Licensee: World Health Organization. EMHJ is an open access journal. This paper is available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo)..
Background: The World Health Organization estimates that there are approximately 5.4 million snakebites and 1.8-2.7 million cases of envenomation, with 81 410-137 880 deaths each year worldwide.
Aims: To estimate the prevalence of neurotoxic and haemotoxic snakebite envenomation through a comprehensive systematic review and meta-analysis.
Methods: We searched Medline/PubMed, Scopus and Cochrane Library up to January 2021 using keywords such as snakebite and snake envenomation. Bibliographic and random searches were also performed. Prospective or retrospective observational studies and randomized controlled trials were included for the review.
Results: We included 271 of 9711 studies published between 1963 and 2020. The pooled prevalence of snakebite from 188 studies with a total of 207 235 participants showed the highest prevalence in North America (69.20%; 95% confidence interval, CI: 57.06-81.34%) and lowest in Africa (28.10%; 95% CI: 22.22-33.98%). There was a pooled prevalence of 24.94% (95% CI: 22.84-27.03%) for haemotoxicity, with a highest prevalence of coagulopathy (43.76%; 95% CI: 33.15-54.37%). The overall prevalence of neurotoxicity was 38.20% (95% CI: 31.88-44.53%), with a highest prevalence of ptosis (53.57%; 95% CI: 38.51-68.62%).
Conclusion: There was a higher prevalence of snakebites in North America. The most prevalent haemotoxicity and neurotoxicity were coagulopathy and ptosis, respectively. The overall quality of evidence was good with a non-significant publication bias.
| Errataetall: |
CommentIn: East Mediterr Health J. 2023 Aug 31;29(8):673-675. - PMID 37698223 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit - 28(2022), 12 vom: 21. Dez., Seite 909-916 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suhita, Ramadugula [VerfasserIn] |
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| Links: |
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| Themen: |
Haemotoxicity |
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| Anmerkungen: |
Date Completed 28.12.2022 Date Revised 06.10.2023 published: Electronic CommentIn: East Mediterr Health J. 2023 Aug 31;29(8):673-675. - PMID 37698223 Citation Status MEDLINE |
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| doi: |
10.26719/emhj.22.090 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350850542 |
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| 245 | 1 | 0 | |a Systematic review and meta-analysis of global prevalence of neurotoxic and hemotoxic snakebite envenomation |
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| 500 | |a Date Revised 06.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a CommentIn: East Mediterr Health J. 2023 Aug 31;29(8):673-675. - PMID 37698223 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © Authors 2022; Licensee: World Health Organization. EMHJ is an open access journal. This paper is available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). | ||
| 520 | |a Background: The World Health Organization estimates that there are approximately 5.4 million snakebites and 1.8-2.7 million cases of envenomation, with 81 410-137 880 deaths each year worldwide | ||
| 520 | |a Aims: To estimate the prevalence of neurotoxic and haemotoxic snakebite envenomation through a comprehensive systematic review and meta-analysis | ||
| 520 | |a Methods: We searched Medline/PubMed, Scopus and Cochrane Library up to January 2021 using keywords such as snakebite and snake envenomation. Bibliographic and random searches were also performed. Prospective or retrospective observational studies and randomized controlled trials were included for the review | ||
| 520 | |a Results: We included 271 of 9711 studies published between 1963 and 2020. The pooled prevalence of snakebite from 188 studies with a total of 207 235 participants showed the highest prevalence in North America (69.20%; 95% confidence interval, CI: 57.06-81.34%) and lowest in Africa (28.10%; 95% CI: 22.22-33.98%). There was a pooled prevalence of 24.94% (95% CI: 22.84-27.03%) for haemotoxicity, with a highest prevalence of coagulopathy (43.76%; 95% CI: 33.15-54.37%). The overall prevalence of neurotoxicity was 38.20% (95% CI: 31.88-44.53%), with a highest prevalence of ptosis (53.57%; 95% CI: 38.51-68.62%) | ||
| 520 | |a Conclusion: There was a higher prevalence of snakebites in North America. The most prevalent haemotoxicity and neurotoxicity were coagulopathy and ptosis, respectively. The overall quality of evidence was good with a non-significant publication bias | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a haemotoxicity | |
| 650 | 4 | |a neurotoxicity | |
| 650 | 4 | |a prevalence | |
| 650 | 4 | |a snakebite | |
| 650 | 4 | |a toxicology | |
| 700 | 1 | |a Begum, Izwath |e verfasserin |4 aut | |
| 700 | 1 | |a Rashid, Muhammed |e verfasserin |4 aut | |
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| 700 | 1 | |a Rajan, Asha K |e verfasserin |4 aut | |
| 700 | 1 | |a Thunga, Girish |e verfasserin |4 aut | |
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