Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms : A prospective follow-up investigation
Copyright © 2022 Alfadda, Rafiullah, Alkhowaiter, Alotaibi, Alzahrani, Binkhamis, Siddiqui, Youssef, Altalhi, Almaghlouth, Alarifi, Albanyan, Alosaimi, Isnani, Nawaz and Alayed..
Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were known to have persisting symptoms of fatigue, headache, dyspnea, and anosmia. There is a need to describe the characteristics of individuals with post-COVID-19 symptoms in comparison to the baseline characteristics.
Purpose: To investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital.
Methods: This was a prospective follow-up investigation of hospitalized and discharged COVID-19 patients. Adult patients admitted to King Saud University Medical City, Riyadh, Saudi Arabia, with laboratory-confirmed COVID-19 and discharged were recruited. The baseline demographic information, comorbidities, vital signs and symptoms, laboratory parameters, COVID-19 therapy, and outcomes were collected from the medical records. Blood samples were collected for cytokines estimation. A detailed interview about signs and symptoms was undertaken during the follow-up.
Results: Half of the followed-up people reported experiencing at least one of the COVID-19-related symptoms. The mean blood pressure was found higher in follow-up. People with the symptoms were characterized by low lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without any post-COVID-19 symptoms. Cytokines IL-8, VEGF, and MCP-1 were higher in people with the most frequent symptoms.
Conclusion: People with post-COVID-19 symptoms were characterized by lower lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without symptoms. Individuals with the most frequent post-COVID-19 symptoms had higher baseline pro-inflammatory, chemotactic, and angiogenic cytokines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Frontiers in medicine - 9(2022) vom: 28., Seite 1067082 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alfadda, Assim A [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 24.12.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fmed.2022.1067082 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350732396 |
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| 100 | 1 | |a Alfadda, Assim A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms |b A prospective follow-up investigation |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022 Alfadda, Rafiullah, Alkhowaiter, Alotaibi, Alzahrani, Binkhamis, Siddiqui, Youssef, Altalhi, Almaghlouth, Alarifi, Albanyan, Alosaimi, Isnani, Nawaz and Alayed. | ||
| 520 | |a Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were known to have persisting symptoms of fatigue, headache, dyspnea, and anosmia. There is a need to describe the characteristics of individuals with post-COVID-19 symptoms in comparison to the baseline characteristics | ||
| 520 | |a Purpose: To investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital | ||
| 520 | |a Methods: This was a prospective follow-up investigation of hospitalized and discharged COVID-19 patients. Adult patients admitted to King Saud University Medical City, Riyadh, Saudi Arabia, with laboratory-confirmed COVID-19 and discharged were recruited. The baseline demographic information, comorbidities, vital signs and symptoms, laboratory parameters, COVID-19 therapy, and outcomes were collected from the medical records. Blood samples were collected for cytokines estimation. A detailed interview about signs and symptoms was undertaken during the follow-up | ||
| 520 | |a Results: Half of the followed-up people reported experiencing at least one of the COVID-19-related symptoms. The mean blood pressure was found higher in follow-up. People with the symptoms were characterized by low lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without any post-COVID-19 symptoms. Cytokines IL-8, VEGF, and MCP-1 were higher in people with the most frequent symptoms | ||
| 520 | |a Conclusion: People with post-COVID-19 symptoms were characterized by lower lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without symptoms. Individuals with the most frequent post-COVID-19 symptoms had higher baseline pro-inflammatory, chemotactic, and angiogenic cytokines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a PASC | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a long COVID | |
| 650 | 4 | |a post-COVID-19 | |
| 700 | 1 | |a Rafiullah, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Alkhowaiter, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Alotaibi, Naif |e verfasserin |4 aut | |
| 700 | 1 | |a Alzahrani, Musa |e verfasserin |4 aut | |
| 700 | 1 | |a Binkhamis, Khalifa |e verfasserin |4 aut | |
| 700 | 1 | |a Siddiqui, Khalid |e verfasserin |4 aut | |
| 700 | 1 | |a Youssef, Amira |e verfasserin |4 aut | |
| 700 | 1 | |a Altalhi, Haifa |e verfasserin |4 aut | |
| 700 | 1 | |a Almaghlouth, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Alarifi, Mohammed |e verfasserin |4 aut | |
| 700 | 1 | |a Albanyan, Saleh |e verfasserin |4 aut | |
| 700 | 1 | |a Alosaimi, Mohammed F |e verfasserin |4 aut | |
| 700 | 1 | |a Isnani, Arthur |e verfasserin |4 aut | |
| 700 | 1 | |a Nawaz, Shaik Sarfaraz |e verfasserin |4 aut | |
| 700 | 1 | |a Alayed, Khalid |e verfasserin |4 aut | |
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