Thyrotropin Levels in Patients with Coronavirus Disease 2019 : Assessment during Hospitalization and in the Medium Term after Discharge
BACKGROUND: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization.
METHODS: We collected data on adult patients hospitalized with COVID-19 at Amiens University Hospital. We compared TSH levels between inpatients with critical (intensive care unit admission and/or death) versus non-critical COVID-19. Thereafter, survivors were invited to return for a three-month post-discharge visit where thyroid function tests were performed, regardless of the availability of TSH measurement during hospitalization.
RESULTS: Among 448 inpatients with COVID-19, TSH assay data during hospitalization were available for 139 patients without prior thyroid disease. Patients with critical and non-critical forms of COVID-19 did not differ significantly with regard to the median (interquartile range) TSH level (0.96 (0.68-1.71) vs. 1.27 mIU/L (0.75-1.79), p = 0.40). Abnormal TSH level was encountered in 17 patients (12.2%); most of them had subclinical thyroid disease. TSH assay data at the three-month post-discharge visit were available for 151 patients without prior thyroid disease. Only seven of them (4.6%) had abnormal TSH levels. Median TSH level at the post-discharge visit was significantly higher than median TSH level during hospitalization.
CONCLUSIONS: Our findings suggest that COVID-19 is associated with a transient suppression of TSH in a minority of patients regardless of the clinical form. The higher TSH levels three months after COVID-19 might suggest recovery from non-thyroidal illness syndrome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Life (Basel, Switzerland) - 12(2022), 12 vom: 02. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Al-Salameh, Abdallah [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 26.12.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/life12122014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350679002 |
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| 100 | 1 | |a Al-Salameh, Abdallah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Thyrotropin Levels in Patients with Coronavirus Disease 2019 |b Assessment during Hospitalization and in the Medium Term after Discharge |
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| 500 | |a Date Revised 26.12.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: The objectives of this study were (1) to compare TSH levels between inpatients with critical versus non-critical coronavirus disease 19 (COVID-19), and (2) to describe the status of TSH levels three months after hospitalization | ||
| 520 | |a METHODS: We collected data on adult patients hospitalized with COVID-19 at Amiens University Hospital. We compared TSH levels between inpatients with critical (intensive care unit admission and/or death) versus non-critical COVID-19. Thereafter, survivors were invited to return for a three-month post-discharge visit where thyroid function tests were performed, regardless of the availability of TSH measurement during hospitalization | ||
| 520 | |a RESULTS: Among 448 inpatients with COVID-19, TSH assay data during hospitalization were available for 139 patients without prior thyroid disease. Patients with critical and non-critical forms of COVID-19 did not differ significantly with regard to the median (interquartile range) TSH level (0.96 (0.68-1.71) vs. 1.27 mIU/L (0.75-1.79), p = 0.40). Abnormal TSH level was encountered in 17 patients (12.2%); most of them had subclinical thyroid disease. TSH assay data at the three-month post-discharge visit were available for 151 patients without prior thyroid disease. Only seven of them (4.6%) had abnormal TSH levels. Median TSH level at the post-discharge visit was significantly higher than median TSH level during hospitalization | ||
| 520 | |a CONCLUSIONS: Our findings suggest that COVID-19 is associated with a transient suppression of TSH in a minority of patients regardless of the clinical form. The higher TSH levels three months after COVID-19 might suggest recovery from non-thyroidal illness syndrome | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a coronavirus disease 2019 | |
| 650 | 4 | |a hypothalamic-pituitary-thyroid axis | |
| 650 | 4 | |a non-thyroidal illness syndrome | |
| 650 | 4 | |a thyroid | |
| 650 | 4 | |a thyroid-stimulating hormone | |
| 700 | 1 | |a Scherman, Noémie |e verfasserin |4 aut | |
| 700 | 1 | |a Adda, Imane |e verfasserin |4 aut | |
| 700 | 1 | |a André, Juliette |e verfasserin |4 aut | |
| 700 | 1 | |a Zerbib, Yoann |e verfasserin |4 aut | |
| 700 | 1 | |a Maizel, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Lalau, Jean-Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Brochot, Etienne |e verfasserin |4 aut | |
| 700 | 1 | |a Andrejak, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Desailloud, Rachel |e verfasserin |4 aut | |
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