Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19
A cytokine storm drives the pathogenesis of severe COVID-19 infection and several biomarkers have been linked to mortality. Chronic kidney disease (CKD) emerged as a risk factor for severe COVID-19. We investigated the association between selected biomarkers and mortality in 77 patients hospitalized for COVID-19, and whether they differ in patients with eGFR higher and lower than 45 mL/min. The association between patients’ characteristics, plasma biomarkers and mortality was conducted by univariate logistic regression models and independent predictors of mortality were then used to create a multivariate prediction model through Cox regression. Patients with lower eGFR had a significant increase of GDF-15, CD-25 and RAGE, with higher plasma levels in non-survivors and in patients who needed ventilation. At univariate analysis, low and mid-low GDF-15 quartiles (<4.45 ng/mL) were associated with lower mortality risk, while mid-high and high quartiles (>4.45 ng/mL) were associated with higher mortality risk. Independent association between GDF-15 quartiles and mortality risk was confirmed in the Cox model and adjusted for eGFR, age, fever and dyspnea (HR 2.28, CI 1.53−3.39, p < 0.0001). The strength of the association between GDF-15 quartiles and mortality risk increased in patients with lower compared to higher eGFR (HR 2.53, CI 1.34−4.79 versus HR 1.99, CI 1.17−3.39). Our findings may suggest a further investigation of the effect of GDF-15 signaling pathway inhibition in CKD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
---|---|
Enthalten in: |
Biomedicines - 10(2022), 12 vom: 14. Dez. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Galassi, Andrea [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 08.03.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/biomedicines10123251 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM350635293 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM350635293 | ||
003 | DE-627 | ||
005 | 20231226045435.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/biomedicines10123251 |2 doi | |
028 | 5 | 2 | |a pubmed24n1168.xml |
035 | |a (DE-627)NLM350635293 | ||
035 | |a (NLM)36552007 | ||
035 | |a (PII)3251 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Galassi, Andrea |e verfasserin |4 aut | |
245 | 1 | 0 | |a Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19 |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 08.03.2023 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a A cytokine storm drives the pathogenesis of severe COVID-19 infection and several biomarkers have been linked to mortality. Chronic kidney disease (CKD) emerged as a risk factor for severe COVID-19. We investigated the association between selected biomarkers and mortality in 77 patients hospitalized for COVID-19, and whether they differ in patients with eGFR higher and lower than 45 mL/min. The association between patients’ characteristics, plasma biomarkers and mortality was conducted by univariate logistic regression models and independent predictors of mortality were then used to create a multivariate prediction model through Cox regression. Patients with lower eGFR had a significant increase of GDF-15, CD-25 and RAGE, with higher plasma levels in non-survivors and in patients who needed ventilation. At univariate analysis, low and mid-low GDF-15 quartiles (<4.45 ng/mL) were associated with lower mortality risk, while mid-high and high quartiles (>4.45 ng/mL) were associated with higher mortality risk. Independent association between GDF-15 quartiles and mortality risk was confirmed in the Cox model and adjusted for eGFR, age, fever and dyspnea (HR 2.28, CI 1.53−3.39, p < 0.0001). The strength of the association between GDF-15 quartiles and mortality risk increased in patients with lower compared to higher eGFR (HR 2.53, CI 1.34−4.79 versus HR 1.99, CI 1.17−3.39). Our findings may suggest a further investigation of the effect of GDF-15 signaling pathway inhibition in CKD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a CKD | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a GDF-15 | |
650 | 4 | |a mortality | |
700 | 1 | |a Ciceri, Paola |e verfasserin |4 aut | |
700 | 1 | |a Bono, Valeria |e verfasserin |4 aut | |
700 | 1 | |a Magagnoli, Lorenza |e verfasserin |4 aut | |
700 | 1 | |a Sala, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Artioli, Luisa |e verfasserin |4 aut | |
700 | 1 | |a Rovito, Roberta |e verfasserin |4 aut | |
700 | 1 | |a Hadla, Mohamad |e verfasserin |4 aut | |
700 | 1 | |a Yellenki, Vaibhav |e verfasserin |4 aut | |
700 | 1 | |a D'Arminio Monforte, Antonella |e verfasserin |4 aut | |
700 | 1 | |a Tincati, Camilla |e verfasserin |4 aut | |
700 | 1 | |a Cozzolino, Mario |e verfasserin |4 aut | |
700 | 1 | |a Marchetti, Giulia |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Biomedicines |d 2013 |g 10(2022), 12 vom: 14. Dez. |w (DE-627)NLM268899797 |x 2227-9059 |7 nnns |
773 | 1 | 8 | |g volume:10 |g year:2022 |g number:12 |g day:14 |g month:12 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/biomedicines10123251 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 10 |j 2022 |e 12 |b 14 |c 12 |