Prognostic Significance of p16 and Its Relationship with Human Papillomavirus Status in Patients with Penile Squamous Cell Carcinoma : Results of 5 Years Follow-Up
Penile Squamous Cell Carcinoma (PSCC) is associated with high-risk human papillomavirus (HR-HPV). The immunohistochemical (IHC) test for p16INK4a (p16) is highly correlated with HR-HPV expression in other SCCs. To investigate whether the expression of p16 IHC or HR-HPV is associated with survival in PSCC, we conducted a single institution analysis of 143 patients with a diagnosis of PSCC and, available tissue were tested for p16 IHC staining patterns, histological subtype, tumor grade, and lymphovascular invasion (LVI) by an experienced pathologist. HR-HPV status using the Cobas PCR Assay or the RNAScope high-risk HPV in situ hybridization kit were also assessed. Patient characteristics were summarized using descriptive statistics of clinico-pathologic variables. Kaplan-Meier was used to estimate median overall survival (OS), cancer specific survival (CSS) and correlated with HPV, p16, and other study variables. Patients with p16+ tumors had a significantly longer median CSS in comparison to the p16- group (p = 0.004), with respective 5-year CSS probability of 88% (95% CI; 0.84, 1) versus 58% (95% CI; 0.55, 0.76; p = 0.004). HPV status did not predict survival outcomes. Multivariable analysis with respect to OS and CSS, showed that p16+ status was associated with a lower risk of death (HR = 0.36, 95%CI; 0.20-0.67, p = 0.001), and improved CSS (HR = 0.20, 95% CI; 0.07-0.54, p = 0.002) after adjusting for covariates. In conclusion, tumor p16 status via IHC was an easy to perform independent prognostic factor for OS and CSS that correlates with HR-HPV expression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Cancers - 14(2022), 24 vom: 07. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chahoud, Jad [VerfasserIn] |
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| Links: |
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| Themen: |
CDKN2A |
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| Anmerkungen: |
Date Revised 01.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/cancers14246024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350630321 |
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| 100 | 1 | |a Chahoud, Jad |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic Significance of p16 and Its Relationship with Human Papillomavirus Status in Patients with Penile Squamous Cell Carcinoma |b Results of 5 Years Follow-Up |
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| 520 | |a Penile Squamous Cell Carcinoma (PSCC) is associated with high-risk human papillomavirus (HR-HPV). The immunohistochemical (IHC) test for p16INK4a (p16) is highly correlated with HR-HPV expression in other SCCs. To investigate whether the expression of p16 IHC or HR-HPV is associated with survival in PSCC, we conducted a single institution analysis of 143 patients with a diagnosis of PSCC and, available tissue were tested for p16 IHC staining patterns, histological subtype, tumor grade, and lymphovascular invasion (LVI) by an experienced pathologist. HR-HPV status using the Cobas PCR Assay or the RNAScope high-risk HPV in situ hybridization kit were also assessed. Patient characteristics were summarized using descriptive statistics of clinico-pathologic variables. Kaplan-Meier was used to estimate median overall survival (OS), cancer specific survival (CSS) and correlated with HPV, p16, and other study variables. Patients with p16+ tumors had a significantly longer median CSS in comparison to the p16- group (p = 0.004), with respective 5-year CSS probability of 88% (95% CI; 0.84, 1) versus 58% (95% CI; 0.55, 0.76; p = 0.004). HPV status did not predict survival outcomes. Multivariable analysis with respect to OS and CSS, showed that p16+ status was associated with a lower risk of death (HR = 0.36, 95%CI; 0.20-0.67, p = 0.001), and improved CSS (HR = 0.20, 95% CI; 0.07-0.54, p = 0.002) after adjusting for covariates. In conclusion, tumor p16 status via IHC was an easy to perform independent prognostic factor for OS and CSS that correlates with HR-HPV expression | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a cancer specific survival | |
| 650 | 4 | |a human papillomavirus | |
| 650 | 4 | |a overall survival | |
| 650 | 4 | |a p16 | |
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| 700 | 1 | |a Zacharias, Niki M |e verfasserin |4 aut | |
| 700 | 1 | |a Pham, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Alaniz, Angelita |e verfasserin |4 aut | |
| 700 | 1 | |a Segarra, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez-Ferrer, Magaly |e verfasserin |4 aut | |
| 700 | 1 | |a Gleber-Netto, Frederico Omar |e verfasserin |4 aut | |
| 700 | 1 | |a Pickering, Curtis R |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Priya |e verfasserin |4 aut | |
| 700 | 1 | |a Pettaway, Curtis A |e verfasserin |4 aut | |
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