Germinal matrix hemorrhage induces immune responses, brain injury, and motor impairment in neonatal rats
Germinal matrix hemorrhage (GMH) is a major complication of prematurity that causes secondary brain injury and is associated with long-term neurological disabilities. This study used a postnatal day 5 rat model of GMH to explore immune response, brain injury, and neurobehavioral changes after hemorrhagic injury. The results showed that CD45high/CD11b+ immune cells increased in the brain after GMH and were accompanied by increased macrophage-related chemokine/cytokines and inflammatory mediators. Hematoma formed as early as 2 h after injection of collagenase VII and white matter injury appeared not only in the external capsule and hippocampus, but also in the thalamus. In addition, GMH caused abnormal motor function as revealed by gait analysis, and locomotor hyperactivity in the elevated plus maze, though no other obvious anxiety or recognition/memory function changes were noted when examined by the open field test and novel object recognition test. The animal model used here partially reproduces the GMH-induced brain injury and motor dysfunction seen in human neonates and therefore can be used as a valid tool in experimental studies for the development of effective therapeutic strategies for GMH-induced brain injury.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 43(2023), 2_suppl vom: 21. Nov., Seite 49-65 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zhang, Xiaoli [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Chemokines |
|---|
| Anmerkungen: |
Date Completed 10.11.2023 Date Revised 18.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1177/0271678X221147091 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM350573786 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM350573786 | ||
| 003 | DE-627 | ||
| 005 | 20231226045314.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/0271678X221147091 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1168.xml |
| 035 | |a (DE-627)NLM350573786 | ||
| 035 | |a (NLM)36545808 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zhang, Xiaoli |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Germinal matrix hemorrhage induces immune responses, brain injury, and motor impairment in neonatal rats |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 10.11.2023 | ||
| 500 | |a Date Revised 18.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Germinal matrix hemorrhage (GMH) is a major complication of prematurity that causes secondary brain injury and is associated with long-term neurological disabilities. This study used a postnatal day 5 rat model of GMH to explore immune response, brain injury, and neurobehavioral changes after hemorrhagic injury. The results showed that CD45high/CD11b+ immune cells increased in the brain after GMH and were accompanied by increased macrophage-related chemokine/cytokines and inflammatory mediators. Hematoma formed as early as 2 h after injection of collagenase VII and white matter injury appeared not only in the external capsule and hippocampus, but also in the thalamus. In addition, GMH caused abnormal motor function as revealed by gait analysis, and locomotor hyperactivity in the elevated plus maze, though no other obvious anxiety or recognition/memory function changes were noted when examined by the open field test and novel object recognition test. The animal model used here partially reproduces the GMH-induced brain injury and motor dysfunction seen in human neonates and therefore can be used as a valid tool in experimental studies for the development of effective therapeutic strategies for GMH-induced brain injury | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Germinal matrix hemorrhage | |
| 650 | 4 | |a chemokines | |
| 650 | 4 | |a cytokines | |
| 650 | 4 | |a immune cells | |
| 650 | 4 | |a motor dysfunction | |
| 700 | 1 | |a Yuan, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wendong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yiran |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hongwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lingling |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Wenjun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jinjin |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaoyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Changlian |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism |d 1993 |g 43(2023), 2_suppl vom: 21. Nov., Seite 49-65 |w (DE-627)NLM012901814 |x 1559-7016 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2023 |g number:2_suppl |g day:21 |g month:11 |g pages:49-65 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/0271678X221147091 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2023 |e 2_suppl |b 21 |c 11 |h 49-65 | ||