Feasibility of Modified Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy : A Retrospective Analysis
© 2022 S. Karger AG, Basel..
BACKGROUND: Endobronchial ultrasound (EBUS)-guided intranodal forceps biopsy (IFB), a diagnostic bronchoscopic technique for intrathoracic lymphadenopathy, is performed following EBUS-guided transbronchial needle aspiration (TBNA). The current EBUS-IFB technique is complex and provides small sample volumes. We modified this technique to allow the use of standard-sized forceps.
OBJECTIVES: The aim of this study was to assess the feasibility of the modified EBUS-IFB technique, which combines standard-sized forceps with standard EBUS-TBNA equipment.
METHOD: This retrospective analysis included consecutive patients scheduled for EBUS-TBNA with attempted additional IFB between July 2020 and March 2021. The feasibility indices of IFB, technical success rate, diagnostic accuracy, and major complications were retrospectively investigated. We performed semi-quantitative evaluation of the histological specimens and univariable analyses to identify factors associated with IFB failure.
RESULTS: During the study period, 295 patients underwent 307 EBUS-TBNAs; 195 cases were included in the analyses. Target lesions were mainly mediastinal lymph nodes (134 cases, 68.7%); the most frequent sites were #7 (61 cases) and #4R (50 cases). The median lesion size was 16.1 mm, the technical IFB success rate was 90.8%, and the diagnostic accuracy of the TBNA and IFB combination was 99.5%. One patient was lost to follow-up. Univariable analyses did not identify any factors involved in technical IFB failure. Major complications of pneumonia and pneumothorax occurred in 2 cases (1.0%). The median histological score was significantly higher in the IFB group than in the TBNA group (1.67 vs. 1.50, p = 0.032).
CONCLUSIONS: Modified EBUS-IFB, combining standard-sized forceps with common EBUS-TBNA equipment, is feasible with few major complications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
Respiration; international review of thoracic diseases - 102(2023), 2 vom: 20., Seite 143-153 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Konno-Yamamoto, Aya [VerfasserIn] |
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| Links: |
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| Themen: |
Bronchoscopy |
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| Anmerkungen: |
Date Completed 07.02.2023 Date Revised 03.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000528644 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM350547351 |
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| 100 | 1 | |a Konno-Yamamoto, Aya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Feasibility of Modified Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy |b A Retrospective Analysis |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 S. Karger AG, Basel. | ||
| 520 | |a BACKGROUND: Endobronchial ultrasound (EBUS)-guided intranodal forceps biopsy (IFB), a diagnostic bronchoscopic technique for intrathoracic lymphadenopathy, is performed following EBUS-guided transbronchial needle aspiration (TBNA). The current EBUS-IFB technique is complex and provides small sample volumes. We modified this technique to allow the use of standard-sized forceps | ||
| 520 | |a OBJECTIVES: The aim of this study was to assess the feasibility of the modified EBUS-IFB technique, which combines standard-sized forceps with standard EBUS-TBNA equipment | ||
| 520 | |a METHOD: This retrospective analysis included consecutive patients scheduled for EBUS-TBNA with attempted additional IFB between July 2020 and March 2021. The feasibility indices of IFB, technical success rate, diagnostic accuracy, and major complications were retrospectively investigated. We performed semi-quantitative evaluation of the histological specimens and univariable analyses to identify factors associated with IFB failure | ||
| 520 | |a RESULTS: During the study period, 295 patients underwent 307 EBUS-TBNAs; 195 cases were included in the analyses. Target lesions were mainly mediastinal lymph nodes (134 cases, 68.7%); the most frequent sites were #7 (61 cases) and #4R (50 cases). The median lesion size was 16.1 mm, the technical IFB success rate was 90.8%, and the diagnostic accuracy of the TBNA and IFB combination was 99.5%. One patient was lost to follow-up. Univariable analyses did not identify any factors involved in technical IFB failure. Major complications of pneumonia and pneumothorax occurred in 2 cases (1.0%). The median histological score was significantly higher in the IFB group than in the TBNA group (1.67 vs. 1.50, p = 0.032) | ||
| 520 | |a CONCLUSIONS: Modified EBUS-IFB, combining standard-sized forceps with common EBUS-TBNA equipment, is feasible with few major complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bronchoscopy | |
| 650 | 4 | |a Intranodal forceps biopsy | |
| 650 | 4 | |a Lymphadenopathy | |
| 650 | 4 | |a Transbronchial needle aspiration | |
| 700 | 1 | |a Matsumoto, Yuji |e verfasserin |4 aut | |
| 700 | 1 | |a Imabayashi, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Midori |e verfasserin |4 aut | |
| 700 | 1 | |a Uchimura, Keigo |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagomi, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yanase, Komei |e verfasserin |4 aut | |
| 700 | 1 | |a So, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Ohe, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuchida, Takaaki |e verfasserin |4 aut | |
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