Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism
© 2022 The Obesity Society..
OBJECTIVE: Roux-en-Y gastric bypass surgery (RYGB) is among the most effective therapies for obesity and type 2 diabetes, and intestinal adaptation is a proposed mechanism for these effects. It was hypothesized that intestinal adaptation precedes and relates to metabolic improvement in humans after RYGB.
METHODS: This was a prospective, longitudinal, first-in-human study of gene expression (GE) in the "Roux limb" (RL) collected surgically/endoscopically from 19 patients with and without diabetes. GE was determined by microarray across six postoperative months, including at an early postoperative (1 month ± 15 days) time point.
RESULTS: RL GE demonstrated tissue remodeling and metabolic reprogramming, including increased glucose and amino acid use. RL GE signatures were established early, before maximal clinical response, and persisted. Distinct GE fingerprints predicted concurrent and future improvements in HbA1c and in weight. Human RL exhibited GE changes characterized by anabolic growth and shift in metabolic substrate use. Paradoxically, anabolic growth in RL appeared to contribute to the catabolic state elicited by RYGB.
CONCLUSIONS: These data support a role for a direct effect of intestinal energy metabolism to contribute to the beneficial clinical effects of RYGB, suggesting that related pathways might be potential targets of therapeutic interest for patients with obesity with or without type 2 diabetes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Obesity (Silver Spring, Md.) - 31(2023), 1 vom: 01. Jan., Seite 49-61 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Stefater-Richards, Margaret A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Blood Glucose |
|---|
| Anmerkungen: |
Date Completed 22.12.2022 Date Revised 02.01.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1002/oby.23585 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM350527903 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM350527903 | ||
| 003 | DE-627 | ||
| 005 | 20240108140646.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/oby.23585 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1246.xml |
| 035 | |a (DE-627)NLM350527903 | ||
| 035 | |a (NLM)36541157 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Stefater-Richards, Margaret A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.12.2022 | ||
| 500 | |a Date Revised 02.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Obesity Society. | ||
| 520 | |a OBJECTIVE: Roux-en-Y gastric bypass surgery (RYGB) is among the most effective therapies for obesity and type 2 diabetes, and intestinal adaptation is a proposed mechanism for these effects. It was hypothesized that intestinal adaptation precedes and relates to metabolic improvement in humans after RYGB | ||
| 520 | |a METHODS: This was a prospective, longitudinal, first-in-human study of gene expression (GE) in the "Roux limb" (RL) collected surgically/endoscopically from 19 patients with and without diabetes. GE was determined by microarray across six postoperative months, including at an early postoperative (1 month ± 15 days) time point | ||
| 520 | |a RESULTS: RL GE demonstrated tissue remodeling and metabolic reprogramming, including increased glucose and amino acid use. RL GE signatures were established early, before maximal clinical response, and persisted. Distinct GE fingerprints predicted concurrent and future improvements in HbA1c and in weight. Human RL exhibited GE changes characterized by anabolic growth and shift in metabolic substrate use. Paradoxically, anabolic growth in RL appeared to contribute to the catabolic state elicited by RYGB | ||
| 520 | |a CONCLUSIONS: These data support a role for a direct effect of intestinal energy metabolism to contribute to the beneficial clinical effects of RYGB, suggesting that related pathways might be potential targets of therapeutic interest for patients with obesity with or without type 2 diabetes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 700 | 1 | |a Panciotti, Courtney |e verfasserin |4 aut | |
| 700 | 1 | |a Feldman, Henry A |e verfasserin |4 aut | |
| 700 | 1 | |a Gourash, William F |e verfasserin |4 aut | |
| 700 | 1 | |a Shirley, Eleanor |e verfasserin |4 aut | |
| 700 | 1 | |a Hutchinson, John N |e verfasserin |4 aut | |
| 700 | 1 | |a Golick, Lena |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Sang W |e verfasserin |4 aut | |
| 700 | 1 | |a Courcoulas, Anita P |e verfasserin |4 aut | |
| 700 | 1 | |a Stylopoulos, Nicholas |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Obesity (Silver Spring, Md.) |d 2006 |g 31(2023), 1 vom: 01. Jan., Seite 49-61 |w (DE-627)NLM160857384 |x 1930-739X |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2023 |g number:1 |g day:01 |g month:01 |g pages:49-61 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/oby.23585 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2023 |e 1 |b 01 |c 01 |h 49-61 | ||