Insulin may promote SARS-CoV-2 cell entry and replication in diabetes patients
© 2022 Elsevier Ltd. All rights reserved..
Patients with diabetes often have severe hyperglycemia triggered by novel coronavirus disease 2019 (COVID-19). Insulin treatment should be the main approach to the control of acute hyperglycemia in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, clinical investigation found that insulin treatment is associated with a significant increase in mortality risk in patients with diabetes and SARS-CoV-2 infection. The reason for this high mortality rate remains obscure. Previous studies have demonstrated that insulin is an activator of Na+/H+ exchanger (NHE) which could decrease extracellular pH and increase intracellular pH and glycolysis. Here, the author emphasizes insulin may contribute to SARS-CoV-2 cell entry and multiplication in host cells through activation of Na+/H+ exchange. Additionally, the inhibition of Na+ /H+ exchange activity or glycolytic flux can result in reduced mortality in patients with COVID-19 and diabetes mellitus during insulin treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:170 |
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| Enthalten in: |
Medical hypotheses - 170(2023) vom: 26. Jan., Seite 110997 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Wenwu [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 22.12.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.mehy.2022.110997 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Patients with diabetes often have severe hyperglycemia triggered by novel coronavirus disease 2019 (COVID-19). Insulin treatment should be the main approach to the control of acute hyperglycemia in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, clinical investigation found that insulin treatment is associated with a significant increase in mortality risk in patients with diabetes and SARS-CoV-2 infection. The reason for this high mortality rate remains obscure. Previous studies have demonstrated that insulin is an activator of Na+/H+ exchanger (NHE) which could decrease extracellular pH and increase intracellular pH and glycolysis. Here, the author emphasizes insulin may contribute to SARS-CoV-2 cell entry and multiplication in host cells through activation of Na+/H+ exchange. Additionally, the inhibition of Na+ /H+ exchange activity or glycolytic flux can result in reduced mortality in patients with COVID-19 and diabetes mellitus during insulin treatment | ||
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