Milk-cereal mix supplementation during infancy and impact on neurodevelopmental outcomes at 12 and 24 months of age : a randomised controlled trial in India
Inadequate protein intake and lack of micronutrients may affect neurodevelopment in infants. This randomised controlled trial was conducted to measure the effect of two milk-cereal mixes with modest and high amounts of protein and enriched with multiple micronutrients, given between 6 and 12 months, on cognitive, language, motor and behavioural scores at 12 and 24 months of age, compared with no-supplementation. The two supplements were also compared with each other. The study was conducted in urban Delhi, India, and the infants were randomised in a 1:1:1 ratio to the three study groups. At 12 and 24 months of age, 1134 and 1214 children were available, respectively. At 12 months of age, compared with no-supplement group, an increase in the motor scores (mean difference, MD 1·52, 95 % CI: 0·28, 2·75) and a decrease in the infant temperament scores (MD - 2·76, 95 % CI: -4·23, -1·29) in the modest-protein group was observed. Those in the high-protein group had lower socio-emotional scores (MD - 1·40, 95 % CI: -2·43, -0·37) and higher scores on Infant Temperament Scale (MD 2·05, 95 % CI: 0·62, 3·48) when compared with modest-protein group. At 24 months, no significant differences in any of the neurodevelopment scores between the three study groups was found. In conclusion, supplementation with modest amount of protein and multiple micronutrients may lead to short-term small improvements in motor function and infant temperament. There appears no advantage of supplementing with high protein, rather negative effects on infant behaviour were observed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
The British journal of nutrition - 130(2023), 5 vom: 14. Sept., Seite 868-877 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Upadhyay, Ravi Prakash [VerfasserIn] |
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| Links: |
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| Themen: |
India |
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| Anmerkungen: |
Date Completed 07.08.2023 Date Revised 09.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1017/S0007114522003944 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350509816 |
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| 100 | 1 | |a Upadhyay, Ravi Prakash |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Milk-cereal mix supplementation during infancy and impact on neurodevelopmental outcomes at 12 and 24 months of age |b a randomised controlled trial in India |
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| 500 | |a Date Revised 09.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Inadequate protein intake and lack of micronutrients may affect neurodevelopment in infants. This randomised controlled trial was conducted to measure the effect of two milk-cereal mixes with modest and high amounts of protein and enriched with multiple micronutrients, given between 6 and 12 months, on cognitive, language, motor and behavioural scores at 12 and 24 months of age, compared with no-supplementation. The two supplements were also compared with each other. The study was conducted in urban Delhi, India, and the infants were randomised in a 1:1:1 ratio to the three study groups. At 12 and 24 months of age, 1134 and 1214 children were available, respectively. At 12 months of age, compared with no-supplement group, an increase in the motor scores (mean difference, MD 1·52, 95 % CI: 0·28, 2·75) and a decrease in the infant temperament scores (MD - 2·76, 95 % CI: -4·23, -1·29) in the modest-protein group was observed. Those in the high-protein group had lower socio-emotional scores (MD - 1·40, 95 % CI: -2·43, -0·37) and higher scores on Infant Temperament Scale (MD 2·05, 95 % CI: 0·62, 3·48) when compared with modest-protein group. At 24 months, no significant differences in any of the neurodevelopment scores between the three study groups was found. In conclusion, supplementation with modest amount of protein and multiple micronutrients may lead to short-term small improvements in motor function and infant temperament. There appears no advantage of supplementing with high protein, rather negative effects on infant behaviour were observed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a India | |
| 650 | 4 | |a Infancy | |
| 650 | 4 | |a Milk protein | |
| 650 | 4 | |a Neurodevelopment | |
| 650 | 4 | |a Nutritional supplementation | |
| 650 | 4 | |a Randomised controlled trial | |
| 650 | 7 | |a Micronutrients |2 NLM | |
| 700 | 1 | |a Taneja, Sunita |e verfasserin |4 aut | |
| 700 | 1 | |a Strand, Tor Arne |e verfasserin |4 aut | |
| 700 | 1 | |a Hysing, Mari |e verfasserin |4 aut | |
| 700 | 1 | |a Koshy, Beena |e verfasserin |4 aut | |
| 700 | 1 | |a Bhandari, Nita |e verfasserin |4 aut | |
| 700 | 1 | |a Bahl, Rajiv |e verfasserin |4 aut | |
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