Epidemiology of haemophagocytic lymphohistiocytosis at the population level in Germany
© 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd..
We retrospectively analysed all German inpatient cases of haemophagocytic lymphohistiocytosis (HLH) from 2014 to 2020 to describe the epidemiology, clinical course, and underlying diseases of 4065 HLH patients. The age-standardized incidence rate of HLH in Germany was 0.52/100 000 people in 2014 and steadily increased by 10% per year to 0.97/100 000 in 2020 (mean 0.70/100 000). Inpatient deaths related to HLH increased from 0.84/1 000 000 people in 2014 to 2.32/1 000 000 people in 2020, caused by rising numbers of older HLH patients. Overall, HLH is more frequent than previously expected and incidence as well as HLH-related deaths increased significantly.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:201 |
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| Enthalten in: |
British journal of haematology - 201(2023), 2 vom: 14. Apr., Seite 285-289 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuron, David [VerfasserIn] |
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| Links: |
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| Themen: |
Epidemiology |
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| Anmerkungen: |
Date Completed 06.04.2023 Date Revised 07.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bjh.18617 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350471037 |
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| 520 | |a © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. | ||
| 520 | |a We retrospectively analysed all German inpatient cases of haemophagocytic lymphohistiocytosis (HLH) from 2014 to 2020 to describe the epidemiology, clinical course, and underlying diseases of 4065 HLH patients. The age-standardized incidence rate of HLH in Germany was 0.52/100 000 people in 2014 and steadily increased by 10% per year to 0.97/100 000 in 2020 (mean 0.70/100 000). Inpatient deaths related to HLH increased from 0.84/1 000 000 people in 2014 to 2.32/1 000 000 people in 2020, caused by rising numbers of older HLH patients. Overall, HLH is more frequent than previously expected and incidence as well as HLH-related deaths increased significantly | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a haemophagocytic lymphohistiocytosis (HLH) | |
| 650 | 4 | |a macrophage activation syndrome (MAS) | |
| 700 | 1 | |a Voran, Jakob Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a von Samson-Himmelstjerna, Friedrich Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Baldus, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Kunzendorf, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Schulte, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Kolbrink, Benedikt |e verfasserin |4 aut | |
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