Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people : A randomized cross-controlled trial
Copyright © 2022 Gu, Chen, Lu, Dai, Hu, Xu, Geng, Zhu, Xu, Dai and Shen..
Objective: To investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people.
Methods: Forty healthy young people were enrolled in this randomized crossover trial. The participants were randomized to receive anodal HD-tDCS (n = 20) or sham HD-tDCS (n = 20) over the left DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data were continuously recorded 20 min before the stimulation, during the session (20 min), and 20 min after the session. HR and the time- and frequency-domain indices of the HRV were measured to investigate the activity of the sympathetic and parasympathetic nervous systems.
Results: Anodal HD-tDCS over the left DLPFC induced a significant decrease in HR and a significant increase in the average of normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), and LF/high-frequency (HF) ratio in comparison with the sham stimulation and the baseline. However, sham HD-tDCS over the left DLPFC had no significant effect on HR or HRV.
Conclusions: Anodal HD-tDCS over the left DLPFC could reduce HR and modulate the HRV in healthy young people. HD-tDCS may show some potential for acutely modulating cardiovascular function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Frontiers in cardiovascular medicine - 9(2022) vom: 14., Seite 1070157 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gu, Zhongke [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiac rhythm |
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| Anmerkungen: |
Date Revised 22.12.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fcvm.2022.1070157 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350435383 |
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| 100 | 1 | |a Gu, Zhongke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people |b A randomized cross-controlled trial |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 22.12.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022 Gu, Chen, Lu, Dai, Hu, Xu, Geng, Zhu, Xu, Dai and Shen. | ||
| 520 | |a Objective: To investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people | ||
| 520 | |a Methods: Forty healthy young people were enrolled in this randomized crossover trial. The participants were randomized to receive anodal HD-tDCS (n = 20) or sham HD-tDCS (n = 20) over the left DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data were continuously recorded 20 min before the stimulation, during the session (20 min), and 20 min after the session. HR and the time- and frequency-domain indices of the HRV were measured to investigate the activity of the sympathetic and parasympathetic nervous systems | ||
| 520 | |a Results: Anodal HD-tDCS over the left DLPFC induced a significant decrease in HR and a significant increase in the average of normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), and LF/high-frequency (HF) ratio in comparison with the sham stimulation and the baseline. However, sham HD-tDCS over the left DLPFC had no significant effect on HR or HRV | ||
| 520 | |a Conclusions: Anodal HD-tDCS over the left DLPFC could reduce HR and modulate the HRV in healthy young people. HD-tDCS may show some potential for acutely modulating cardiovascular function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cardiac rhythm | |
| 650 | 4 | |a dorsolateral pre-frontal cortex | |
| 650 | 4 | |a heart rate | |
| 650 | 4 | |a heart-rate variability | |
| 650 | 4 | |a high-definition transcranial current stimulation | |
| 700 | 1 | |a Chen, Wenxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Jiansong |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Shugang |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Boqing |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Wenjun |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Ying |e verfasserin |4 aut | |
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