Mild and asymptomatic influenza B virus infection among unvaccinated pregnant persons : Implication for effectiveness of non-pharmaceutical intervention and vaccination to prevent influenza
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: We estimated symptomatic and asymptomatic influenza infection frequency in community-dwelling unvaccinated pregnant persons to inform risk communication.
METHODS: We collected residue sera from multiple antenatal-care blood draws during October 2016-April 2017. We determined influenza infection as seroconversion with ≥ 4-fold rise in antibody titers between any two serum samples by improved hemagglutinin-inhibition assay including ether-treated B antigens. The serology data were linked to the results of nuclei acid testing (rRT-PCR) based on acute respiratory illness (ARI) surveillance.
RESULTS: Among all participants, 43 %(602/1384) demonstrated serology and/or rRT-PCR evidenced infection, and 44 %(265/602) of all infections were asymptomatic. ARI-associated rRT-PCR testing identified only 10 %(61/602) of total infections. Only 1 %(5/420) of the B Victoria cases reported ARI and had a rRT-PCR positive result, compared with 33 %(54/165) of the H3N2 cases. Among influenza ARI cases with multiple serum samples, 19 %(11/58) had seroconversion to a different subtype prior to the illness.
CONCLUSIONS: The incidence of influenza B infection in unvaccinated pregnant persons is under-estimated substantially. Non-pharmaceutical intervention may have suboptimal effectiveness in preventing influenza B transmission due to the less clinical manifestation compared to influenza A. The findings support maternal influenza vaccination to protect pregnant persons and reduce consequent household transmission.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Vaccine - 41(2023), 3 vom: 16. Jan., Seite 694-701 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Liling [VerfasserIn] |
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| Links: |
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| Themen: |
Influenza Vaccines |
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| Anmerkungen: |
Date Completed 03.01.2023 Date Revised 10.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.vaccine.2022.11.055 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM350383766 |
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| 100 | 1 | |a Chen, Liling |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mild and asymptomatic influenza B virus infection among unvaccinated pregnant persons |b Implication for effectiveness of non-pharmaceutical intervention and vaccination to prevent influenza |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: We estimated symptomatic and asymptomatic influenza infection frequency in community-dwelling unvaccinated pregnant persons to inform risk communication | ||
| 520 | |a METHODS: We collected residue sera from multiple antenatal-care blood draws during October 2016-April 2017. We determined influenza infection as seroconversion with ≥ 4-fold rise in antibody titers between any two serum samples by improved hemagglutinin-inhibition assay including ether-treated B antigens. The serology data were linked to the results of nuclei acid testing (rRT-PCR) based on acute respiratory illness (ARI) surveillance | ||
| 520 | |a RESULTS: Among all participants, 43 %(602/1384) demonstrated serology and/or rRT-PCR evidenced infection, and 44 %(265/602) of all infections were asymptomatic. ARI-associated rRT-PCR testing identified only 10 %(61/602) of total infections. Only 1 %(5/420) of the B Victoria cases reported ARI and had a rRT-PCR positive result, compared with 33 %(54/165) of the H3N2 cases. Among influenza ARI cases with multiple serum samples, 19 %(11/58) had seroconversion to a different subtype prior to the illness | ||
| 520 | |a CONCLUSIONS: The incidence of influenza B infection in unvaccinated pregnant persons is under-estimated substantially. Non-pharmaceutical intervention may have suboptimal effectiveness in preventing influenza B transmission due to the less clinical manifestation compared to influenza A. The findings support maternal influenza vaccination to protect pregnant persons and reduce consequent household transmission | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Influenza virus infection | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Seroconversion | |
| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Levine, Min Z |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Suizan |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Yuanyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Bao, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Yayun |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Pengwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Millman, Alexander J |e verfasserin |4 aut | |
| 700 | 1 | |a Greene, Carolyn M |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhongwei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jun |e verfasserin |4 aut | |
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