Improving equity in access to early diagnosis of cancer in different healthcare systems of Latin America : protocol for the EquityCancer-LA implementation-effectiveness hybrid study
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ..
INTRODUCTION: Healthcare fragmentation, a main cause for delay in cancer diagnosis and treatment, contributes to high mortality in Latin America (LA), particularly among disadvantaged populations. This research focuses on integrated care interventions, which have been limitedly implemented in the region. The objective is to evaluate the contextual effectiveness of scaling-up an integrated care intervention to improve early diagnosis of frequent cancers in healthcare networks of Chile, Colombia and Ecuador.
METHODS AND ANALYSIS: This research is two pronged: (A) quasi-experimental design (controlled before and after) with an intervention and a control healthcare network in each LA country, using an implementation-effectiveness hybrid approach to assess the intervention process, effectiveness and costs; and (B) case study design to analyse access to diagnosis of most frequent cancers. Focusing on the most vulnerable socioeconomic population, it develops in four phases: (1) analysis of delays and barriers to early diagnosis (baseline); (2) intervention adaptation and implementation (primary care training, fast-track referral pathway and patient information); (3) intracountry evaluation of intervention and (4) cross-country analysis. Baseline and evaluation studies adopt mixed-methods qualitative (semistructured individual interviews) and quantitative (patient questionnaire survey) methods. For the latter, a sample size of 174 patients with cancer diagnosis per healthcare network and year was calculated to detect a proportions difference of 15%, before and after intervention (α=0.05; β=0.2) in a two-sided test. A participatory approach will be used to tailor the intervention to each context, led by a local steering committee (professionals, managers, policy makers, patients and researchers).
ETHICS AND DISSEMINATION: This study complies with international and national legal stipulations on ethics. It was approved by each country's ethical committee and informed consent will be obtained from participants. Besides the coproduction of knowledge with key stakeholders, it will be disseminated through strategies such as policy briefs, workshops, e-tools and scientific papers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
BMJ open - 12(2022), 12 vom: 13. Dez., Seite e067439 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vázquez, Maria-Luisa [VerfasserIn] |
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| Links: |
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| Themen: |
Adult oncology |
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| Anmerkungen: |
Date Completed 19.12.2022 Date Revised 22.12.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bmjopen-2022-067439 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Improving equity in access to early diagnosis of cancer in different healthcare systems of Latin America |b protocol for the EquityCancer-LA implementation-effectiveness hybrid study |
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| 500 | |a Date Revised 22.12.2022 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. | ||
| 520 | |a INTRODUCTION: Healthcare fragmentation, a main cause for delay in cancer diagnosis and treatment, contributes to high mortality in Latin America (LA), particularly among disadvantaged populations. This research focuses on integrated care interventions, which have been limitedly implemented in the region. The objective is to evaluate the contextual effectiveness of scaling-up an integrated care intervention to improve early diagnosis of frequent cancers in healthcare networks of Chile, Colombia and Ecuador | ||
| 520 | |a METHODS AND ANALYSIS: This research is two pronged: (A) quasi-experimental design (controlled before and after) with an intervention and a control healthcare network in each LA country, using an implementation-effectiveness hybrid approach to assess the intervention process, effectiveness and costs; and (B) case study design to analyse access to diagnosis of most frequent cancers. Focusing on the most vulnerable socioeconomic population, it develops in four phases: (1) analysis of delays and barriers to early diagnosis (baseline); (2) intervention adaptation and implementation (primary care training, fast-track referral pathway and patient information); (3) intracountry evaluation of intervention and (4) cross-country analysis. Baseline and evaluation studies adopt mixed-methods qualitative (semistructured individual interviews) and quantitative (patient questionnaire survey) methods. For the latter, a sample size of 174 patients with cancer diagnosis per healthcare network and year was calculated to detect a proportions difference of 15%, before and after intervention (α=0.05; β=0.2) in a two-sided test. A participatory approach will be used to tailor the intervention to each context, led by a local steering committee (professionals, managers, policy makers, patients and researchers) | ||
| 520 | |a ETHICS AND DISSEMINATION: This study complies with international and national legal stipulations on ethics. It was approved by each country's ethical committee and informed consent will be obtained from participants. Besides the coproduction of knowledge with key stakeholders, it will be disseminated through strategies such as policy briefs, workshops, e-tools and scientific papers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a adult oncology | |
| 650 | 4 | |a change management | |
| 650 | 4 | |a health policy | |
| 650 | 4 | |a medical education & training | |
| 650 | 4 | |a organisation of health services | |
| 650 | 4 | |a quality in health care | |
| 700 | 1 | |a Vargas, Ingrid |e verfasserin |4 aut | |
| 700 | 1 | |a Rubio-Valera, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Aznar-Lou, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Eguiguren, Pamela |e verfasserin |4 aut | |
| 700 | 1 | |a Mogollón-Pérez, Amparo-Susana |e verfasserin |4 aut | |
| 700 | 1 | |a Torres, Ana-Lucía |e verfasserin |4 aut | |
| 700 | 1 | |a Peralta, Andrés |e verfasserin |4 aut | |
| 700 | 1 | |a Dias, Sónia |e verfasserin |4 aut | |
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| 700 | 1 | |a Vazquez, M L |e investigator |4 oth | |
| 700 | 1 | |a Oliver, Aida |e investigator |4 oth | |
| 700 | 1 | |a Espinel, Verónica |e investigator |4 oth | |
| 700 | 1 | |a Fernández, Zahara |e investigator |4 oth | |
| 700 | 1 | |a Borràs, Josep Maria |e investigator |4 oth | |
| 700 | 1 | |a Gil-Girbau, Montserrat |e investigator |4 oth | |
| 700 | 1 | |a Serrano-Blanco, Antoni |e investigator |4 oth | |
| 700 | 1 | |a Arroyo-Uriarte, Paula |e investigator |4 oth | |
| 700 | 1 | |a Garmendia, María Luisa |e investigator |4 oth | |
| 700 | 1 | |a Oyarce, Ana María |e investigator |4 oth | |
| 700 | 1 | |a Bass, Camilo |e investigator |4 oth | |
| 700 | 1 | |a Guzmán, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Alvarez, Andrea |e investigator |4 oth | |
| 700 | 1 | |a González, Paola |e investigator |4 oth | |
| 700 | 1 | |a Abarca, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Stock, Rodney |e investigator |4 oth | |
| 700 | 1 | |a Cerda, Berta |e investigator |4 oth | |
| 700 | 1 | |a Hartwig, Guillermo |e investigator |4 oth | |
| 700 | 1 | |a Tabilo, Cristopher |e investigator |4 oth | |
| 700 | 1 | |a Aravena, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Stephens, Gloria |e investigator |4 oth | |
| 700 | 1 | |a Garcia, Virginia |e investigator |4 oth | |
| 700 | 1 | |a Pedraza, Ana Maria |e investigator |4 oth | |
| 700 | 1 | |a Pinzón, Angela |e investigator |4 oth | |
| 700 | 1 | |a Cardozo, Carol |e investigator |4 oth | |
| 700 | 1 | |a Rangel, María Camila |e investigator |4 oth | |
| 700 | 1 | |a Cristancho, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Mantilla, William |e investigator |4 oth | |
| 700 | 1 | |a León, Guillermo |e investigator |4 oth | |
| 700 | 1 | |a Merchán, Juan |e investigator |4 oth | |
| 700 | 1 | |a Dueñas, Iván |e investigator |4 oth | |
| 700 | 1 | |a Pereira, Hugo |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, Estefanía |e investigator |4 oth | |
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