Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease
Published by Elsevier B.V..
Human infection with Sosuga virus (SOSV), a recently discovered pathogenic paramyxovirus, has been reported in one individual to date. No animal models of disease are currently available for SOSV. Here, we describe initial characterization of experimental infection in Syrian hamsters, including kinetics of virus dissemination and replication, and the corresponding clinical parameters, immunological responses, and histopathology. We demonstrate susceptibility of hamsters to infection in the absence of clinical signs or significant histopathologic findings in tissues.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:209 |
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| Enthalten in: |
Antiviral research - 209(2023) vom: 20. Jan., Seite 105490 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Welch, Stephen R [VerfasserIn] |
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| Links: |
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| Themen: |
Hamster animal model |
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| Anmerkungen: |
Date Completed 17.01.2023 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.antiviral.2022.105490 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Human infection with Sosuga virus (SOSV), a recently discovered pathogenic paramyxovirus, has been reported in one individual to date. No animal models of disease are currently available for SOSV. Here, we describe initial characterization of experimental infection in Syrian hamsters, including kinetics of virus dissemination and replication, and the corresponding clinical parameters, immunological responses, and histopathology. We demonstrate susceptibility of hamsters to infection in the absence of clinical signs or significant histopathologic findings in tissues | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Hamster animal model | |
| 650 | 4 | |a Histopathology | |
| 650 | 4 | |a Neutralization | |
| 650 | 4 | |a Paramyxovirus | |
| 650 | 4 | |a Sosuga virus | |
| 650 | 4 | |a Zoonoses | |
| 700 | 1 | |a Ritter, Jana M |e verfasserin |4 aut | |
| 700 | 1 | |a Schuh, Amy J |e verfasserin |4 aut | |
| 700 | 1 | |a Genzer, Sarah C |e verfasserin |4 aut | |
| 700 | 1 | |a Sorvillo, Teresa E |e verfasserin |4 aut | |
| 700 | 1 | |a Harmon, Jessica R |e verfasserin |4 aut | |
| 700 | 1 | |a Coleman-McCray, JoAnn D |e verfasserin |4 aut | |
| 700 | 1 | |a Jain, Shilpi |e verfasserin |4 aut | |
| 700 | 1 | |a Shrivastava-Ranjan, Punya |e verfasserin |4 aut | |
| 700 | 1 | |a Seixas, Josilene Nascimento |e verfasserin |4 aut | |
| 700 | 1 | |a Estetter, Lindsey B |e verfasserin |4 aut | |
| 700 | 1 | |a Fair, Pamela S |e verfasserin |4 aut | |
| 700 | 1 | |a Towner, Jonathan S |e verfasserin |4 aut | |
| 700 | 1 | |a Montgomery, Joel M |e verfasserin |4 aut | |
| 700 | 1 | |a Albariño, César G |e verfasserin |4 aut | |
| 700 | 1 | |a Spiropoulou, Christina F |e verfasserin |4 aut | |
| 700 | 1 | |a Spengler, Jessica R |e verfasserin |4 aut | |
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