Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment
© 2022. The Author(s), under exclusive licence to World Molecular Imaging Society..
The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components (e.g., fibroblasts, mesenchymal stromal cells, immune cells, extracellular matrix, blood vessels) provide a promising strategy to target these biomarkers for the early diagnosis of cancers. Moreover, various cancer types have similar tumor immune microenvironment (TIME) features that targeting those biomarkers and offer clinically translatable molecular imaging of cancers. In this review, we categorize and summarize the components in TME which have been targeted for molecular imaging. Moreover, this review updated the recent progress in targeted imaging of TIME biological molecules by various modalities for the early detection of cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Molecular imaging and biology - 25(2023), 3 vom: 15. Juni, Seite 464-482 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Siminzar, Paniz [VerfasserIn] |
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| Links: |
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| Themen: |
Biological aspects |
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| Anmerkungen: |
Date Completed 12.05.2023 Date Revised 09.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11307-022-01795-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350296944 |
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| 520 | |a © 2022. The Author(s), under exclusive licence to World Molecular Imaging Society. | ||
| 520 | |a The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components (e.g., fibroblasts, mesenchymal stromal cells, immune cells, extracellular matrix, blood vessels) provide a promising strategy to target these biomarkers for the early diagnosis of cancers. Moreover, various cancer types have similar tumor immune microenvironment (TIME) features that targeting those biomarkers and offer clinically translatable molecular imaging of cancers. In this review, we categorize and summarize the components in TME which have been targeted for molecular imaging. Moreover, this review updated the recent progress in targeted imaging of TIME biological molecules by various modalities for the early detection of cancer | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Biological aspects | |
| 650 | 4 | |a Molecular imaging biomarkers | |
| 650 | 4 | |a Tumor immune microenvironment (TIME) | |
| 650 | 4 | |a Tumor targeting | |
| 700 | 1 | |a Tohidkia, Mohammad Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Eppard, Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Vahidfar, Nasim |e verfasserin |4 aut | |
| 700 | 1 | |a Tarighatnia, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Aghanejad, Ayuob |e verfasserin |4 aut | |
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