Adolescent-onset TAFRO Syndrome with Malignant Nephrosclerosis-like Lesions
A 16-year-old Japanese girl developed a fever, thrombocytopenia, and renal dysfunction. Treatment was started with steroids, but cervical lymphadenopathy and ascites developed. A lymph node biopsy indicated TAFRO syndrome. The patient's renal function deteriorated, and dialysis was started. Refractory hypertension and subsequent encephalopathy developed. Treatment was started with an anti-IL-6 receptor antibody and an anti-CD20 monoclonal antibody. A kidney biopsy showed malignant nephrosclerosis-like microangiopathy and glomerular collapse due to narrowing of the small arteries. The majority of TAFRO syndrome cases are adult-onset, with glomerular microangiopathy. To our knowledge, this is the first report of adolescent-onset TAFRO syndrome presenting with malignant nephrosclerosis-like lesions associated with hypertension.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 62(2023), 15 vom: 01. Aug., Seite 2223-2229 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nakayama, Yuki [VerfasserIn] |
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| Links: |
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| Themen: |
Adolescent onset |
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| Anmerkungen: |
Date Completed 04.08.2023 Date Revised 31.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.0529-22 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350290008 |
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| 520 | |a A 16-year-old Japanese girl developed a fever, thrombocytopenia, and renal dysfunction. Treatment was started with steroids, but cervical lymphadenopathy and ascites developed. A lymph node biopsy indicated TAFRO syndrome. The patient's renal function deteriorated, and dialysis was started. Refractory hypertension and subsequent encephalopathy developed. Treatment was started with an anti-IL-6 receptor antibody and an anti-CD20 monoclonal antibody. A kidney biopsy showed malignant nephrosclerosis-like microangiopathy and glomerular collapse due to narrowing of the small arteries. The majority of TAFRO syndrome cases are adult-onset, with glomerular microangiopathy. To our knowledge, this is the first report of adolescent-onset TAFRO syndrome presenting with malignant nephrosclerosis-like lesions associated with hypertension | ||
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| 650 | 4 | |a adolescent onset | |
| 650 | 4 | |a malignant hypertension | |
| 700 | 1 | |a Mizuno, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Sawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Suwabe, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yamanouchi, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ikuma, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Eiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshino, Junichi |e verfasserin |4 aut | |
| 700 | 1 | |a Sekine, Akinari |e verfasserin |4 aut | |
| 700 | 1 | |a Oba, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kono, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Kinowaki, Keiichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ohashi, Kenichi |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kodai |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Yasuharu |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Ubara, Yoshifumi |e verfasserin |4 aut | |
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