Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection : a report from the Japan COVID-19 Task Force
© 2022. The Author(s)..
BACKGROUND: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.
METHODS: We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021.
RESULTS: Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave.
CONCLUSIONS: We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
BMC infectious diseases - 22(2022), 1 vom: 12. Dez., Seite 935 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Ho [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 14.12.2022 Date Revised 21.12.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-022-07927-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM350223327 |
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| 100 | 1 | |a Lee, Ho |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection |b a report from the Japan COVID-19 Task Force |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 21.12.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a BACKGROUND: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant | ||
| 520 | |a METHODS: We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021 | ||
| 520 | |a RESULTS: Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave | ||
| 520 | |a CONCLUSIONS: We identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Respiratory infection | |
| 650 | 4 | |a Wave of infection | |
| 700 | 1 | |a Chubachi, Shotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Namkoong, Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Asakura, Takanori |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Hiromu |e verfasserin |4 aut | |
| 700 | 1 | |a Otake, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawara, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Morita, Atsuho |e verfasserin |4 aut | |
| 700 | 1 | |a Fukushima, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Watase, Mayuko |e verfasserin |4 aut | |
| 700 | 1 | |a Kusumoto, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Masaki, Katsunori |e verfasserin |4 aut | |
| 700 | 1 | |a Kamata, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Harada, Norihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Soichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ishiguro, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Arimura, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Fukuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshiyama, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakano, Yasushi |e verfasserin |4 aut | |
| 700 | 1 | |a Mutoh, Yoshikazu |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Murakami, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Yukinori |e verfasserin |4 aut | |
| 700 | 1 | |a Koike, Ryuji |e verfasserin |4 aut | |
| 700 | 1 | |a Kitagawa, Yuko |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Akinori |e verfasserin |4 aut | |
| 700 | 1 | |a Imoto, Seiya |e verfasserin |4 aut | |
| 700 | 1 | |a Miyano, Satoru |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Seishi |e verfasserin |4 aut | |
| 700 | 1 | |a Kanai, Takanori |e verfasserin |4 aut | |
| 700 | 1 | |a Fukunaga, Koichi |e verfasserin |4 aut | |
| 700 | 0 | |a Japan COVID-19 Task Force |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Ho |e investigator |4 oth | |
| 700 | 1 | |a Chubachi, Shotaro |e investigator |4 oth | |
| 700 | 1 | |a Namkoong, Ho |e investigator |4 oth | |
| 700 | 1 | |a Asakura, Takanori |e investigator |4 oth | |
| 700 | 1 | |a Tanaka, Hiromu |e investigator |4 oth | |
| 700 | 1 | |a Otake, Shiro |e investigator |4 oth | |
| 700 | 1 | |a Nakagawara, Kensuke |e investigator |4 oth | |
| 700 | 1 | |a Morita, Atsuho |e investigator |4 oth | |
| 700 | 1 | |a Fukushima, Takahiro |e investigator |4 oth | |
| 700 | 1 | |a Watase, Mayuko |e investigator |4 oth | |
| 700 | 1 | |a Kusumoto, Tatsuya |e investigator |4 oth | |
| 700 | 1 | |a Masaki, Katsunori |e investigator |4 oth | |
| 700 | 1 | |a Kamata, Hirofumi |e investigator |4 oth | |
| 700 | 1 | |a Ishii, Makoto |e investigator |4 oth | |
| 700 | 1 | |a Hasegawa, Naoki |e investigator |4 oth | |
| 700 | 1 | |a Harada, Norihiro |e investigator |4 oth | |
| 700 | 1 | |a Ueda, Tetsuya |e investigator |4 oth | |
| 700 | 1 | |a Ueda, Soichiro |e investigator |4 oth | |
| 700 | 1 | |a Ishiguro, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Arimura, Ken |e investigator |4 oth | |
| 700 | 1 | |a Saito, Fukuki |e investigator |4 oth | |
| 700 | 1 | |a Yoshiyama, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Nakano, Yasushi |e investigator |4 oth | |
| 700 | 1 | |a Mutoh, Yoshikazu |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, Yusuke |e investigator |4 oth | |
| 700 | 1 | |a Murakami, Koji |e investigator |4 oth | |
| 700 | 1 | |a Okada, Yukinori |e investigator |4 oth | |
| 700 | 1 | |a Koike, Ryuji |e investigator |4 oth | |
| 700 | 1 | |a Kitagawa, Yuko |e investigator |4 oth | |
| 700 | 1 | |a Kimura, Akinori |e investigator |4 oth | |
| 700 | 1 | |a Imoto, Seiya |e investigator |4 oth | |
| 700 | 1 | |a Miyano, Satoru |e investigator |4 oth | |
| 700 | 1 | |a Ogawa, Seishi |e investigator |4 oth | |
| 700 | 1 | |a Kanai, Takanori |e investigator |4 oth | |
| 700 | 1 | |a Fukunaga, Koichi |e investigator |4 oth | |
| 700 | 1 | |a Takahashi, Kazuhisa |e investigator |4 oth | |
| 700 | 1 | |a Naito, Toshio |e investigator |4 oth | |
| 700 | 1 | |a Hiki, Makoto |e investigator |4 oth | |
| 700 | 1 | |a Matsushita, Yasushi |e investigator |4 oth | |
| 700 | 1 | |a Takagi, Haruhi |e investigator |4 oth | |
| 700 | 1 | |a Aoki, Ryousuke |e investigator |4 oth | |
| 700 | 1 | |a Nakamura, Ai |e investigator |4 oth | |
| 700 | 1 | |a Harada, Sonoko |e investigator |4 oth | |
| 700 | 1 | |a Sasano, Hitoshi |e investigator |4 oth | |
| 700 | 1 | |a Masaki, Katsunori |e investigator |4 oth | |
| 700 | 1 | |a Ikemura, Shinnosuke |e investigator |4 oth | |
| 700 | 1 | |a Okamori, Satoshi |e investigator |4 oth | |
| 700 | 1 | |a Terai, Hideki |e investigator |4 oth | |
| 700 | 1 | |a Asakura, Takanori |e investigator |4 oth | |
| 700 | 1 | |a Sasaki, Junichi |e investigator |4 oth | |
| 700 | 1 | |a Morisaki, Hiroshi |e investigator |4 oth | |
| 700 | 1 | |a Uwamino, Yoshifumi |e investigator |4 oth | |
| 700 | 1 | |a Nanki, Kosaku |e investigator |4 oth | |
| 700 | 1 | |a Mikami, Yohei |e investigator |4 oth | |
| 700 | 1 | |a Uchida, Sho |e investigator |4 oth | |
| 700 | 1 | |a Uno, Shunsuke |e investigator |4 oth | |
| 700 | 1 | |a Ishihara, Rino |e investigator |4 oth | |
| 700 | 1 | |a Matsubara, Yuta |e investigator |4 oth | |
| 700 | 1 | |a Nishimura, Tomoyasu |e investigator |4 oth | |
| 700 | 1 | |a Ogawa, Takunori |e investigator |4 oth | |
| 700 | 1 | |a Sato, Toshiro |e investigator |4 oth | |
| 700 | 1 | |a Azuma, Masanori |e investigator |4 oth | |
| 700 | 1 | |a Saito, Ryuichi |e investigator |4 oth | |
| 700 | 1 | |a Sado, Toshikatsu |e investigator |4 oth | |
| 700 | 1 | |a Miyazaki, Yoshimune |e investigator |4 oth | |
| 700 | 1 | |a Sato, Ryuichi |e investigator |4 oth | |
| 700 | 1 | |a Haruta, Yuki |e investigator |4 oth | |
| 700 | 1 | |a Nagasaki, Tadao |e investigator |4 oth | |
| 700 | 1 | |a Yasui, Yoshinori |e investigator |4 oth | |
| 700 | 1 | |a Hasegawa, Yoshinori |e investigator |4 oth | |
| 700 | 1 | |a Tada, Ai |e investigator |4 oth | |
| 700 | 1 | |a Miyawaki, Masayoshi |e investigator |4 oth | |
| 700 | 1 | |a Yamamoto, Masaomi |e investigator |4 oth | |
| 700 | 1 | |a Yoshida, Eriko |e investigator |4 oth | |
| 700 | 1 | |a Hayashi, Reina |e investigator |4 oth | |
| 700 | 1 | |a Nagasaka, Tomoki |e investigator |4 oth | |
| 700 | 1 | |a Arai, Sawako |e investigator |4 oth | |
| 700 | 1 | |a Kaneko, Yutaro |e investigator |4 oth | |
| 700 | 1 | |a Sasaki, Kana |e investigator |4 oth | |
| 700 | 1 | |a Isono, Taisuke |e investigator |4 oth | |
| 700 | 1 | |a Shibata, Shun |e investigator |4 oth | |
| 700 | 1 | |a Matsui, Yuma |e investigator |4 oth | |
| 700 | 1 | |a Hosoda, Chiaki |e investigator |4 oth | |
| 700 | 1 | |a Takano, Kenji |e investigator |4 oth | |
| 700 | 1 | |a Nishida, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, Yoichi |e investigator |4 oth | |
| 700 | 1 | |a Takaku, Yotaro |e investigator |4 oth | |
| 700 | 1 | |a Takayanagi, Noboru |e investigator |4 oth | |
| 700 | 1 | |a Tagaya, Etsuko |e investigator |4 oth | |
| 700 | 1 | |a Kawana, Masatoshi |e investigator |4 oth | |
| 700 | 1 | |a Nakamori, Yasushi |e investigator |4 oth | |
| 700 | 1 | |a Yoshiya, Kazuhisa |e investigator |4 oth | |
| 700 | 1 | |a Saito, Fukuki |e investigator |4 oth | |
| 700 | 1 | |a Yoshihara, Tomoyuki |e investigator |4 oth | |
| 700 | 1 | |a Wada, Daiki |e investigator |4 oth | |
| 700 | 1 | |a Iwamura, Hiromu |e investigator |4 oth | |
| 700 | 1 | |a Kanayama, Syuji |e investigator |4 oth | |
| 700 | 1 | |a Maruyama, Shuhei |e investigator |4 oth | |
| 700 | 1 | |a Hasegawa, Takanori |e investigator |4 oth | |
| 700 | 1 | |a Takahashi, Kunihiko |e investigator |4 oth | |
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