Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany..
PURPOSE: Metabolic changes during the perinatal period are known to promote obesity and type-2 diabetes in adulthood via perturbation of the microbiota. The risk factors for metabolic disorders include a high-fat diet (HFD) and exposure to pesticide residues. The objective of the present study was to evaluate the effects of perigestational exposure to a HFD and chlorpyrifos (CPF) on glycemia, lipid profiles, and microbial populations in Wistar dams and their female offspring. We also tested a preventive strategy based on treatment with the prebiotic inulin.
METHODS: From 4 months before gestation to the end of the lactation period, six groups of dams were exposed to either a standard diet, a HFD alone, CPF alone, a combination of a HFD and CPF, and/or inulin supplementation. All female offspring were fed a standard diet from weaning to adulthood. We measured the impacts of these exposures on glycemia, the lipid profile, and the microbiota (composition, metabolite production, and translocation into tissues).
RESULTS: HFD exposure and CPF + HFD co-exposure induced dysmetabolism and an imbalance in the gut flora in both the dams and the female offspring. Inulin mitigated the impact of exposure to a HFD alone but not that of CPF + HFD co-exposure.
CONCLUSION: Our results provide a better understanding of the complex interactions between environmental pollutants and diet in early life, including in the context of metabolic diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
European journal of nutrition - 62(2023), 3 vom: 12. Apr., Seite 1253-1265 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Djekkoun, Narimane [VerfasserIn] |
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| Links: |
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| Themen: |
9005-80-5 |
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| Anmerkungen: |
Date Completed 23.03.2023 Date Revised 23.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00394-022-03063-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350221286 |
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| 245 | 1 | 0 | |a Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 23.03.2023 | ||
| 500 | |a Date Revised 23.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. | ||
| 520 | |a PURPOSE: Metabolic changes during the perinatal period are known to promote obesity and type-2 diabetes in adulthood via perturbation of the microbiota. The risk factors for metabolic disorders include a high-fat diet (HFD) and exposure to pesticide residues. The objective of the present study was to evaluate the effects of perigestational exposure to a HFD and chlorpyrifos (CPF) on glycemia, lipid profiles, and microbial populations in Wistar dams and their female offspring. We also tested a preventive strategy based on treatment with the prebiotic inulin | ||
| 520 | |a METHODS: From 4 months before gestation to the end of the lactation period, six groups of dams were exposed to either a standard diet, a HFD alone, CPF alone, a combination of a HFD and CPF, and/or inulin supplementation. All female offspring were fed a standard diet from weaning to adulthood. We measured the impacts of these exposures on glycemia, the lipid profile, and the microbiota (composition, metabolite production, and translocation into tissues) | ||
| 520 | |a RESULTS: HFD exposure and CPF + HFD co-exposure induced dysmetabolism and an imbalance in the gut flora in both the dams and the female offspring. Inulin mitigated the impact of exposure to a HFD alone but not that of CPF + HFD co-exposure | ||
| 520 | |a CONCLUSION: Our results provide a better understanding of the complex interactions between environmental pollutants and diet in early life, including in the context of metabolic diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dysmetabolism | |
| 650 | 4 | |a High-fat diet | |
| 650 | 4 | |a Microbiota | |
| 650 | 4 | |a Perigestational period | |
| 650 | 4 | |a Pesticide | |
| 650 | 4 | |a Prebiotic | |
| 650 | 7 | |a Prebiotics |2 NLM | |
| 650 | 7 | |a Pesticides |2 NLM | |
| 650 | 7 | |a Inulin |2 NLM | |
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| 650 | 7 | |a Chlorpyrifos |2 NLM | |
| 650 | 7 | |a JCS58I644W |2 NLM | |
| 650 | 7 | |a Lipids |2 NLM | |
| 700 | 1 | |a Depeint, Flore |e verfasserin |4 aut | |
| 700 | 1 | |a Guibourdenche, Marion |e verfasserin |4 aut | |
| 700 | 1 | |a Sabbouri, Hiba El Khayat Et |e verfasserin |4 aut | |
| 700 | 1 | |a Corona, Aurélie |e verfasserin |4 aut | |
| 700 | 1 | |a Rhazi, Larbi |e verfasserin |4 aut | |
| 700 | 1 | |a Gay-Queheillard, Jerome |e verfasserin |4 aut | |
| 700 | 1 | |a Rouabah, Leila |e verfasserin |4 aut | |
| 700 | 1 | |a Biendo, Maurice |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Salameh, Abdallah |e verfasserin |4 aut | |
| 700 | 1 | |a Lalau, Jean-Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Bach, Véronique |e verfasserin |4 aut | |
| 700 | 1 | |a Khorsi-Cauet, Hafida |e verfasserin |4 aut | |
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