Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake
Copyright © 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved..
Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2-9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Obesity research & clinical practice - 17(2023), 1 vom: 13. Jan., Seite 91-93 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Kai [VerfasserIn] |
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| Links: |
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| Themen: |
Calorie restriction |
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| Anmerkungen: |
Date Completed 14.02.2023 Date Revised 15.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.orcp.2022.12.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM35021803X |
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| 520 | |a Copyright © 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2-9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF | ||
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| 650 | 4 | |a Calorie restriction | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Growth differentiation factor 15 | |
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| 650 | 4 | |a Intermittent fasting | |
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| 700 | 1 | |a Hutchison, Amy T |e verfasserin |4 aut | |
| 700 | 1 | |a Heilbronn, Leonie K |e verfasserin |4 aut | |
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