Strategic white matter hyperintensity locations for cognitive impairment : A multicenter lesion-symptom mapping study in 3525 memory clinic patients
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association..
INTRODUCTION: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study.
METHODS: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses.
RESULTS: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains.
DISCUSSION: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment.
HIGHLIGHTS: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 19(2023), 6 vom: 13. Juni, Seite 2420-2432 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 13.06.2023 Date Revised 16.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/alz.12827 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350165432 |
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| 100 | 1 | |a Coenen, Mirthe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Strategic white matter hyperintensity locations for cognitive impairment |b A multicenter lesion-symptom mapping study in 3525 memory clinic patients |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 13.06.2023 | ||
| 500 | |a Date Revised 16.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. | ||
| 520 | |a INTRODUCTION: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study | ||
| 520 | |a METHODS: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses | ||
| 520 | |a RESULTS: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains | ||
| 520 | |a DISCUSSION: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment | ||
| 520 | |a HIGHLIGHTS: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cognitive impairment | |
| 650 | 4 | |a lesion symptom mapping | |
| 650 | 4 | |a location | |
| 650 | 4 | |a memory clinic patients | |
| 650 | 4 | |a white matter hyperintensities | |
| 700 | 1 | |a Kuijf, Hugo J |e verfasserin |4 aut | |
| 700 | 1 | |a Huenges Wajer, Irene M C |e verfasserin |4 aut | |
| 700 | 1 | |a Duering, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Wolters, Frank J |e verfasserin |4 aut | |
| 700 | 1 | |a Fletcher, Evan F |e verfasserin |4 aut | |
| 700 | 1 | |a Maillard, Pauline M |e verfasserin |4 aut | |
| 700 | 0 | |a Alzheimer's Disease Neuroimaging Initiative |e verfasserin |4 aut | |
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