Building sustainable clinical trial sites in Sub-Saharan Africa through networking, infrastructure improvement, training and conducting clinical studies : The PanACEA approach
Copyright © 2022 Elsevier B.V. All rights reserved..
INTRODUCTION: The Pan-African Consortium for the Evaluation of Anti-Tuberculosis Antibiotics (PanACEA) was designed to build tuberculosis (TB) trial capacity whilst conducting clinical trials on novel and existing agents to shorten and simplify TB treatment. PanACEA has now established a dynamic network of 11 sub-Saharan clinical trial sites and four European research institutions.
OBJECTIVES: In 2011, a capacity development program, funded by the European & Developing Countries Clinical Trials Partnership (EDCTP), was launched with four objectives, aiming at strengthening collaborating TB research sites to reach the ultimate goal of becoming self-sustainable institutions: networking; training; conducting clinical trials; and infrastructure scaling-up of sites.
METHODS: Assessment in six sub-Saharan TB-endemic countries (Gabon, Kenya, South Africa, Tanzania, Uganda and Zambia) were performed through a structured questionnaire, site visits, discussion with the PanACEA consortium, setting of milestones and identification of priorities and followed-up with evaluations of each site. The results of this needs-based assessment was then translated into capacity development measures.
RESULTS: In the initial phase, over a four-year period (March 2011 - June 2014), the programme scaled-up six sites; conducted a monitoring training program for 11 participants; funded five MSc and four PhD students, fostering gender balance; conducted four epidemiological studies; supported sites to conduct five Phase II studies and formed a sustainable platform for TB research (panacea-tb.net).
CONCLUSION: Our experience of conducting TB clinical trials within the PanACEA programme environment of mentoring, networking and training has provided a sound platform for establishing future sustainable research centres. Our goal of facilitating emergent clinical TB trial sites to better initiate and lead research activities has been mostly successful.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:238 |
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| Enthalten in: |
Acta tropica - 238(2023) vom: 30. Feb., Seite 106776 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mekota, Anna-Maria [VerfasserIn] |
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| Links: |
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| Themen: |
Capacity development |
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| Anmerkungen: |
Date Completed 12.01.2023 Date Revised 12.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.actatropica.2022.106776 |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Mekota, Anna-Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Building sustainable clinical trial sites in Sub-Saharan Africa through networking, infrastructure improvement, training and conducting clinical studies |b The PanACEA approach |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier B.V. All rights reserved. | ||
| 520 | |a INTRODUCTION: The Pan-African Consortium for the Evaluation of Anti-Tuberculosis Antibiotics (PanACEA) was designed to build tuberculosis (TB) trial capacity whilst conducting clinical trials on novel and existing agents to shorten and simplify TB treatment. PanACEA has now established a dynamic network of 11 sub-Saharan clinical trial sites and four European research institutions | ||
| 520 | |a OBJECTIVES: In 2011, a capacity development program, funded by the European & Developing Countries Clinical Trials Partnership (EDCTP), was launched with four objectives, aiming at strengthening collaborating TB research sites to reach the ultimate goal of becoming self-sustainable institutions: networking; training; conducting clinical trials; and infrastructure scaling-up of sites | ||
| 520 | |a METHODS: Assessment in six sub-Saharan TB-endemic countries (Gabon, Kenya, South Africa, Tanzania, Uganda and Zambia) were performed through a structured questionnaire, site visits, discussion with the PanACEA consortium, setting of milestones and identification of priorities and followed-up with evaluations of each site. The results of this needs-based assessment was then translated into capacity development measures | ||
| 520 | |a RESULTS: In the initial phase, over a four-year period (March 2011 - June 2014), the programme scaled-up six sites; conducted a monitoring training program for 11 participants; funded five MSc and four PhD students, fostering gender balance; conducted four epidemiological studies; supported sites to conduct five Phase II studies and formed a sustainable platform for TB research (panacea-tb.net) | ||
| 520 | |a CONCLUSION: Our experience of conducting TB clinical trials within the PanACEA programme environment of mentoring, networking and training has provided a sound platform for establishing future sustainable research centres. Our goal of facilitating emergent clinical TB trial sites to better initiate and lead research activities has been mostly successful | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Capacity development | |
| 650 | 4 | |a Infrastructure upgrade | |
| 650 | 4 | |a Networking | |
| 650 | 4 | |a Sub-Saharan Africa | |
| 650 | 4 | |a Sustainability | |
| 650 | 4 | |a Training | |
| 700 | 1 | |a Gillespie, Stephen H |e verfasserin |4 aut | |
| 700 | 1 | |a Hoelscher, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Diacon, Andreas H |e verfasserin |4 aut | |
| 700 | 1 | |a Dawson, Rodney |e verfasserin |4 aut | |
| 700 | 1 | |a Churchyard, Gavin |e verfasserin |4 aut | |
| 700 | 1 | |a Sanne, Ian |e verfasserin |4 aut | |
| 700 | 1 | |a Minja, Lilian |e verfasserin |4 aut | |
| 700 | 1 | |a Kibiki, Gibson |e verfasserin |4 aut | |
| 700 | 1 | |a Maboko, Leonard |e verfasserin |4 aut | |
| 700 | 1 | |a Lakhi, Shabir |e verfasserin |4 aut | |
| 700 | 1 | |a Joloba, Moses |e verfasserin |4 aut | |
| 700 | 1 | |a Alabi, Abraham |e verfasserin |4 aut | |
| 700 | 1 | |a Kirenga, Bruce |e verfasserin |4 aut | |
| 700 | 1 | |a McHugh, Timothy D |e verfasserin |4 aut | |
| 700 | 1 | |a Grobusch, Martin P |e verfasserin |4 aut | |
| 700 | 1 | |a Boeree, Martin J |e verfasserin |4 aut | |
| 700 | 0 | |a PanACEA consortium |e verfasserin |4 aut | |
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