Sarcopenia in patients with pancreatic cancer, an independant prognostic factor
Thieme. All rights reserved..
BACKGROUND: Pancreatic cancer is despite modern diagnostic tools and treatment regimen associated with poor outcome. Many patients show cachexia and sarcopenia.
METHODS: In a retrospective analysis the SMI (cm²/m²) was measured by determining the skelettal muscle area in a computed tomography image at lumbar vertebrae 3. Further clinical parameters were measured to determine the outcome.
RESULTS: The mean survival after diagnosis in the population with sarcopenia was significantly lower (14,4 vs 17,7 months, p=0,046). Significantly shorter survival was also seen for higher age (p=0,006), no tumor resection (p=0,004), metastases (p=0,002) and high CA19-9 level (p=0,002) CONCLUSION: Sarcopenia is an indipendant prognostic factor in patients with pancreatic cancer. SMI should be measured clinical practice and further studies are necessary to asses a potential therapeutic strategy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Zeitschrift fur Gastroenterologie - 61(2023), 10 vom: 08. Okt., Seite 1365-1370 |
| Sprache: |
Deutsch |
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| Weiterer Titel: |
Sarkopenie als unabhängiger Prognosefaktor bei Pankreaskarzinom |
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| Beteiligte Personen: |
Mandl, Johanna [VerfasserIn] |
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| Anmerkungen: |
Date Completed 16.10.2023 Date Revised 13.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1055/a-1959-2894 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349943877 |
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| 245 | 1 | 0 | |a Sarcopenia in patients with pancreatic cancer, an independant prognostic factor |
| 246 | 3 | 3 | |a Sarkopenie als unabhängiger Prognosefaktor bei Pankreaskarzinom |
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| 500 | |a Date Completed 16.10.2023 | ||
| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Thieme. All rights reserved. | ||
| 520 | |a BACKGROUND: Pancreatic cancer is despite modern diagnostic tools and treatment regimen associated with poor outcome. Many patients show cachexia and sarcopenia | ||
| 520 | |a METHODS: In a retrospective analysis the SMI (cm²/m²) was measured by determining the skelettal muscle area in a computed tomography image at lumbar vertebrae 3. Further clinical parameters were measured to determine the outcome | ||
| 520 | |a RESULTS: The mean survival after diagnosis in the population with sarcopenia was significantly lower (14,4 vs 17,7 months, p=0,046). Significantly shorter survival was also seen for higher age (p=0,006), no tumor resection (p=0,004), metastases (p=0,002) and high CA19-9 level (p=0,002) CONCLUSION: Sarcopenia is an indipendant prognostic factor in patients with pancreatic cancer. SMI should be measured clinical practice and further studies are necessary to asses a potential therapeutic strategy | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Baumer, Sebastian |e verfasserin |4 aut | |
| 700 | 1 | |a Holtzem, Bernadette |e verfasserin |4 aut | |
| 700 | 1 | |a Theurer, Rainer |e verfasserin |4 aut | |
| 700 | 1 | |a Zorger, Niels |e verfasserin |4 aut | |
| 700 | 1 | |a Pech, Oliver |e verfasserin |4 aut | |
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