The preparation and characterisation of tasteless core-shell clarithromycin microcapsules
This study aims to fabricate core-shell clarithromycin (CAM) microcapsules to cover up the bitter taste of CAM by spray drying with aqueous polymer dispersion. Water dispersion of Eudragit EPO and Surelease® were innovatively used to encapsulate CAM into microcapsules via a one-step spray-drying method. The inlet air temperature, airflow rate, CAM-polymer ratio, and particle size of CAM were optimised based on drug content and T6% (the time taken for the drug to release equal to 6% w/w). The powder properties were assessed by measuring particle size and microstructure using SEM, FT-IR, and PXRD. Furthermore, selected batch was assessed for their drug content, encapsulation efficiency, in vitro release, bitterness, and stability studies. EPO-Surelease® (1: 4) microcapsules had an average diameter (D50) of 37.69 ± 3.61 μm with a span of 2.395. The drug contents and encapsulation efficiency of EPO-Surelease®(1:4) were 10.89% and 63.7%, respectively. EPO-Surelease® (1:4) microcapsules prepared by spray drying with aqueous polymer dispersion can effectively mask the bitter taste of CAM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 7-8 vom: 07. Nov., Seite 654-667 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fu, Yu [VerfasserIn] |
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| Links: |
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| Themen: |
059QF0KO0R |
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| Anmerkungen: |
Date Completed 13.01.2023 Date Revised 13.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2022.2146221 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349887209 |
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| 100 | 1 | |a Fu, Yu |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The preparation and characterisation of tasteless core-shell clarithromycin microcapsules |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study aims to fabricate core-shell clarithromycin (CAM) microcapsules to cover up the bitter taste of CAM by spray drying with aqueous polymer dispersion. Water dispersion of Eudragit EPO and Surelease® were innovatively used to encapsulate CAM into microcapsules via a one-step spray-drying method. The inlet air temperature, airflow rate, CAM-polymer ratio, and particle size of CAM were optimised based on drug content and T6% (the time taken for the drug to release equal to 6% w/w). The powder properties were assessed by measuring particle size and microstructure using SEM, FT-IR, and PXRD. Furthermore, selected batch was assessed for their drug content, encapsulation efficiency, in vitro release, bitterness, and stability studies. EPO-Surelease® (1: 4) microcapsules had an average diameter (D50) of 37.69 ± 3.61 μm with a span of 2.395. The drug contents and encapsulation efficiency of EPO-Surelease®(1:4) were 10.89% and 63.7%, respectively. EPO-Surelease® (1:4) microcapsules prepared by spray drying with aqueous polymer dispersion can effectively mask the bitter taste of CAM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Tasteless | |
| 650 | 4 | |a aqueous polymer dispersion | |
| 650 | 4 | |a clarithromycin | |
| 650 | 4 | |a microcapsules | |
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| 700 | 1 | |a Zhu, Yunjing |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Yihan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaolin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Anan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Zhiqing |e verfasserin |4 aut | |
| 700 | 1 | |a Gou, Jingxin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yanjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Tian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a He, Haibing |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Xing |e verfasserin |4 aut | |
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