Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever
OBJECTIVE: To evaluate the power of the systemic immune-inflammation index in the prediction of mortality in severe Crimean-Congo hemorrhagic fever patients.
STUDY DESIGN: Observational study.
PLACE AND DURATION OF STUDY: Department of Anaesthesiology and Reanimation, Sivas Cumhuriyet University, Sivas, Turkey, from January to June 2022.
METHODOLOGY: Intensive care patients diagnosed with Crimean-Congo hemorrhagic fever, between January 2012 and January 2022, were included. Demographic data, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index were recorded. Receiver operating characteristic analysis, Cox regression analysis and Kaplan-Meier mortality analyses were done.
RESULTS: A cut-off value <1.85 for neutrophil to lymphocyte ratio showed 41.67% sensitivity and 97.06% specificity. A cut-off value <80.75 for the systemic immune-inflammation index showed 84.72% sensitivity and 76.47% specificity. A cut-off value <37.86 for platelet-to- lymphocyte ratio showed 84.72% sensitivity and 73.53% specificity. In patients with systemic immune-inflammation index value <80.75, the mortality rate increased 2.549 times and 3.732 times in patients with a platelet-to-lymphocyte ratio value <37.86.
CONCLUSION: Similar sensitivity and specificity levels were found for systemic immune-inflammation index and platel-to-lymphocyte ratio regarding the mortality prediction power and impact on mortality. Both tests can be used for the prediction of mortality during the hemorrhagic period in patients with severe Crimean-Congo Hemorrhagic Fever.
KEY WORDS: Crimean-congo hemorrhagic fever, Systemic immune inflammation index, Mortality, Platelet-to-lymphocyte ratio.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP - 32(2022), 12 vom: 26. Dez., Seite 1538-1543 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gundogdu, Oguz [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.12.2022 Date Revised 15.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.29271/jcpsp.2022.12.1538 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349867984 |
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| 500 | |a Date Revised 15.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To evaluate the power of the systemic immune-inflammation index in the prediction of mortality in severe Crimean-Congo hemorrhagic fever patients | ||
| 520 | |a STUDY DESIGN: Observational study | ||
| 520 | |a PLACE AND DURATION OF STUDY: Department of Anaesthesiology and Reanimation, Sivas Cumhuriyet University, Sivas, Turkey, from January to June 2022 | ||
| 520 | |a METHODOLOGY: Intensive care patients diagnosed with Crimean-Congo hemorrhagic fever, between January 2012 and January 2022, were included. Demographic data, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index were recorded. Receiver operating characteristic analysis, Cox regression analysis and Kaplan-Meier mortality analyses were done | ||
| 520 | |a RESULTS: A cut-off value <1.85 for neutrophil to lymphocyte ratio showed 41.67% sensitivity and 97.06% specificity. A cut-off value <80.75 for the systemic immune-inflammation index showed 84.72% sensitivity and 76.47% specificity. A cut-off value <37.86 for platelet-to- lymphocyte ratio showed 84.72% sensitivity and 73.53% specificity. In patients with systemic immune-inflammation index value <80.75, the mortality rate increased 2.549 times and 3.732 times in patients with a platelet-to-lymphocyte ratio value <37.86 | ||
| 520 | |a CONCLUSION: Similar sensitivity and specificity levels were found for systemic immune-inflammation index and platel-to-lymphocyte ratio regarding the mortality prediction power and impact on mortality. Both tests can be used for the prediction of mortality during the hemorrhagic period in patients with severe Crimean-Congo Hemorrhagic Fever | ||
| 520 | |a KEY WORDS: Crimean-congo hemorrhagic fever, Systemic immune inflammation index, Mortality, Platelet-to-lymphocyte ratio | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
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