A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing
Copyright © 2022 Society of Biological Psychiatry. All rights reserved..
BACKGROUND: The central amygdala (CeA) is a bilateral hub of pain and emotional processing with well-established functional lateralization. We reported that optogenetic manipulation of neural activity in the left and right CeA has opposing effects on bladder pain.
METHODS: To determine the influence of calcitonin gene-related peptide (CGRP) signaling from the parabrachial nucleus on this diametrically opposed lateralization, we administered CGRP and evaluated the activity of CeA neurons in acute brain slices as well as the behavioral signs of bladder pain in the mouse.
RESULTS: We found that CGRP increased firing in both the right and left CeA neurons. Furthermore, we found that CGRP administration in the right CeA increased behavioral signs of bladder pain and decreased bladder pain-like behavior when administered in the left CeA.
CONCLUSIONS: These studies reveal a parabrachial-to-amygdala circuit driven by opposing actions of CGRP that determines hemispheric lateralization of visceral pain.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
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| Enthalten in: |
Biological psychiatry - 93(2023), 4 vom: 15. Feb., Seite 370-381 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Allen, Heather N [VerfasserIn] |
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| Links: |
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| Themen: |
Amygdala |
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| Anmerkungen: |
Date Completed 20.01.2023 Date Revised 16.02.2024 published: Print-Electronic ErratumIn: Biol Psychiatry. 2024 Feb 14;:. - PMID 38363245 Citation Status MEDLINE |
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| doi: |
10.1016/j.biopsych.2022.09.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349861854 |
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| 245 | 1 | 2 | |a A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing |
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| 500 | |a Date Completed 20.01.2023 | ||
| 500 | |a Date Revised 16.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Biol Psychiatry. 2024 Feb 14;:. - PMID 38363245 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Society of Biological Psychiatry. All rights reserved. | ||
| 520 | |a BACKGROUND: The central amygdala (CeA) is a bilateral hub of pain and emotional processing with well-established functional lateralization. We reported that optogenetic manipulation of neural activity in the left and right CeA has opposing effects on bladder pain | ||
| 520 | |a METHODS: To determine the influence of calcitonin gene-related peptide (CGRP) signaling from the parabrachial nucleus on this diametrically opposed lateralization, we administered CGRP and evaluated the activity of CeA neurons in acute brain slices as well as the behavioral signs of bladder pain in the mouse | ||
| 520 | |a RESULTS: We found that CGRP increased firing in both the right and left CeA neurons. Furthermore, we found that CGRP administration in the right CeA increased behavioral signs of bladder pain and decreased bladder pain-like behavior when administered in the left CeA | ||
| 520 | |a CONCLUSIONS: These studies reveal a parabrachial-to-amygdala circuit driven by opposing actions of CGRP that determines hemispheric lateralization of visceral pain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Amygdala | |
| 650 | 4 | |a CGRP | |
| 650 | 4 | |a Lateralization | |
| 650 | 4 | |a Neuropeptide | |
| 650 | 4 | |a Pain | |
| 650 | 4 | |a Parabrachial nucleus | |
| 650 | 7 | |a Calcitonin Gene-Related Peptide |2 NLM | |
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| 700 | 1 | |a Hong, Veronica M |e verfasserin |4 aut | |
| 700 | 1 | |a Lewter, Lakeisha A |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Ghanshyam P |e verfasserin |4 aut | |
| 700 | 1 | |a Carrasquillo, Yarimar |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Bradley K |e verfasserin |4 aut | |
| 700 | 1 | |a Kolber, Benedict J |e verfasserin |4 aut | |
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