Impact of Oxidative Stress on Embryogenesis and Fetal Development
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG..
Multiple cellular processes are regulated by oxygen radicals or reactive oxygen species (ROS) where they play crucial roles as primary or secondary messengers, particularly during cell proliferation, differentiation, and apoptosis. Embryogenesis and organogenesis encompass all these processes; therefore, their role during these crucial life events cannot be ignored, more so when there is an imbalance in redox homeostasis. Perturbed redox homeostasis is responsible for damaging the biomolecules such as lipids, proteins, and nucleic acids resulting in leaky membrane, altered protein, enzyme function, and DNA damage which have adverse impact on the embryo and fetal development. In this article, we attempt to summarize the available data in literature for an in-depth understanding of redox regulation during development that may help in optimizing the pregnancy outcome both under natural and assisted conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1391 |
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| Enthalten in: |
Advances in experimental medicine and biology - 1391(2022) vom: 06., Seite 221-241 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Swain, Nirlipta [VerfasserIn] |
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| Links: |
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| Themen: |
Embryogenesis |
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| Anmerkungen: |
Date Completed 15.12.2022 Date Revised 15.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-3-031-12966-7_13 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Multiple cellular processes are regulated by oxygen radicals or reactive oxygen species (ROS) where they play crucial roles as primary or secondary messengers, particularly during cell proliferation, differentiation, and apoptosis. Embryogenesis and organogenesis encompass all these processes; therefore, their role during these crucial life events cannot be ignored, more so when there is an imbalance in redox homeostasis. Perturbed redox homeostasis is responsible for damaging the biomolecules such as lipids, proteins, and nucleic acids resulting in leaky membrane, altered protein, enzyme function, and DNA damage which have adverse impact on the embryo and fetal development. In this article, we attempt to summarize the available data in literature for an in-depth understanding of redox regulation during development that may help in optimizing the pregnancy outcome both under natural and assisted conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Embryogenesis | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Placental remodeling | |
| 650 | 4 | |a Reactive oxygen species | |
| 700 | 1 | |a Moharana, Ajaya Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Jena, Soumya Ranjan |e verfasserin |4 aut | |
| 700 | 1 | |a Samanta, Luna |e verfasserin |4 aut | |
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