Single nucleotide polymorphisms rs7799039 and rs2167270 in leptin gene and elevated serum levels of adiponectin predispose Iranians to Behçet's disease
Copyright © 2022 Elsevier Ltd. All rights reserved..
BACKGROUND: Behçet's Disease (BD) is a chronic autoimmune disease with unknown etiology. Adipokines due to their roles in the regulation of immune responses might be important in the induction and progression of BD.
SUBJECTS AND METHODS: This case-control study included 340 patients with BD and 310 healthy controls. Single nucleotide polymorphisms (SNPs) in adiponectin (rs266729 and rs1501299) and leptin (rs7799039 and rs2167270) genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and serum levels of adipokines were measured using enzyme-linked immunosorbent assay (ELISA).
RESULTS: A higher frequency of leptin rs7799039 GG, AG, and AG +GG genotypes and G allele was revealed in patients. Besides, patients had more leptin rs2167270 AG and AG +AA genotypes and A allele. Furthermore, rs2167270 AA genotype and A allele were more frequently seen in total and female patients who had genital aphthous. Patients had significantly more serum levels of adiponectin while those with genital aphthous had significantly more leptin levels. No significant association was observed between genotypes and alleles of adiponectin SNPs and BD.
CONCLUSION: Our findings indicated that leptin gene polymorphisms might predispose Iranian individuals to BD. Besides, elevated serum levels of adiponectin might facilitate BD pathogenesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:162 |
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| Enthalten in: |
Cytokine - 162(2023) vom: 15. Feb., Seite 156100 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kahmini, Fatemeh Rezaei [VerfasserIn] |
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| Links: |
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| Themen: |
Adipokines |
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| Anmerkungen: |
Date Completed 16.01.2023 Date Revised 21.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cyto.2022.156100 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Single nucleotide polymorphisms rs7799039 and rs2167270 in leptin gene and elevated serum levels of adiponectin predispose Iranians to Behçet's disease |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 21.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Behçet's Disease (BD) is a chronic autoimmune disease with unknown etiology. Adipokines due to their roles in the regulation of immune responses might be important in the induction and progression of BD | ||
| 520 | |a SUBJECTS AND METHODS: This case-control study included 340 patients with BD and 310 healthy controls. Single nucleotide polymorphisms (SNPs) in adiponectin (rs266729 and rs1501299) and leptin (rs7799039 and rs2167270) genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and serum levels of adipokines were measured using enzyme-linked immunosorbent assay (ELISA) | ||
| 520 | |a RESULTS: A higher frequency of leptin rs7799039 GG, AG, and AG +GG genotypes and G allele was revealed in patients. Besides, patients had more leptin rs2167270 AG and AG +AA genotypes and A allele. Furthermore, rs2167270 AA genotype and A allele were more frequently seen in total and female patients who had genital aphthous. Patients had significantly more serum levels of adiponectin while those with genital aphthous had significantly more leptin levels. No significant association was observed between genotypes and alleles of adiponectin SNPs and BD | ||
| 520 | |a CONCLUSION: Our findings indicated that leptin gene polymorphisms might predispose Iranian individuals to BD. Besides, elevated serum levels of adiponectin might facilitate BD pathogenesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adiponectin | |
| 650 | 4 | |a Autoimmunity | |
| 650 | 4 | |a Behçet's disease | |
| 650 | 4 | |a Leptin | |
| 650 | 4 | |a Single nucleotide polymorphism | |
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| 650 | 7 | |a Leptin |2 NLM | |
| 650 | 7 | |a Adipokines |2 NLM | |
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| 700 | 1 | |a Amirghofran, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Daryabor, Gholamreza |e verfasserin |4 aut | |
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