Multicentre observational study on multisystem inflammatory syndrome related to COVID-19 in Argentina
© 2022 Japan Pediatric Society..
BACKGROUND: The impact of the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in low- and middle-income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS-TS in Argentina.
METHODS: This observational, prospective, and retrospective multicenter study enrolled patients younger than 18 years-old manifesting PIMS-TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) between March 2020 and May 2021. Patients were followed-up until hospital discharge or death (one case). The primary outcome was pediatric intensive care unit (PICU) admission. Multiple logistic regression was used to identify variables predicting PICU admission.
RESULTS: Eighty-one percent, 82%, and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS-TS, KD, and KSS, respectively. Temporal association with SARS-CoV-2 was confirmed in 85% of the patients and 38% were admitted to the PICU. The more common clinical manifestations were fever, abdominal pain, rash, and conjunctival injection. Lymphopenia was more common among PICU-admitted patients (87% vs. 51%, p < 0.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion, and coronary artery alterations were observed in 30%, 30%, 19.8%, and 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count were significant independent contributions to PICU admission.
CONCLUSION: Rates of severe outcomes of PIMS-TS in the present study agreed with those observed in high-income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
Pediatrics international : official journal of the Japan Pediatric Society - 65(2023), 1 vom: 23. Jan., Seite e15431 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vainstein, Eduardo [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 24.02.2023 Date Revised 24.02.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/ped.15431 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349774587 |
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| 100 | 1 | |a Vainstein, Eduardo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multicentre observational study on multisystem inflammatory syndrome related to COVID-19 in Argentina |
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| 500 | |a Date Revised 24.02.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Japan Pediatric Society. | ||
| 520 | |a BACKGROUND: The impact of the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in low- and middle-income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS-TS in Argentina | ||
| 520 | |a METHODS: This observational, prospective, and retrospective multicenter study enrolled patients younger than 18 years-old manifesting PIMS-TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) between March 2020 and May 2021. Patients were followed-up until hospital discharge or death (one case). The primary outcome was pediatric intensive care unit (PICU) admission. Multiple logistic regression was used to identify variables predicting PICU admission | ||
| 520 | |a RESULTS: Eighty-one percent, 82%, and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS-TS, KD, and KSS, respectively. Temporal association with SARS-CoV-2 was confirmed in 85% of the patients and 38% were admitted to the PICU. The more common clinical manifestations were fever, abdominal pain, rash, and conjunctival injection. Lymphopenia was more common among PICU-admitted patients (87% vs. 51%, p < 0.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion, and coronary artery alterations were observed in 30%, 30%, 19.8%, and 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count were significant independent contributions to PICU admission | ||
| 520 | |a CONCLUSION: Rates of severe outcomes of PIMS-TS in the present study agreed with those observed in high-income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Kawasaki disease | |
| 650 | 4 | |a Kawasaki shock syndrome | |
| 650 | 4 | |a multisystem inflammatory syndrome in children | |
| 650 | 4 | |a pediatric multisystem inflammatory syndrome | |
| 700 | 1 | |a Baleani, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Urrutia, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Affranchino, Nicolás |e verfasserin |4 aut | |
| 700 | 1 | |a Ackerman, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Cazalas, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Goldsman, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Sardella, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Tolin, Ana Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Goldaracena, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Fabi, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Cosentino, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Magliola, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Roggiero, Gustavo |e verfasserin |4 aut | |
| 700 | 1 | |a Manso, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Triguy, Jésica |e verfasserin |4 aut | |
| 700 | 1 | |a Ballester, Celeste |e verfasserin |4 aut | |
| 700 | 1 | |a Cervetto, Vanesa |e verfasserin |4 aut | |
| 700 | 1 | |a Vaccarello, María |e verfasserin |4 aut | |
| 700 | 1 | |a De Carli, Domingo Norberto |e verfasserin |4 aut | |
| 700 | 1 | |a De Carli, Maria Estela |e verfasserin |4 aut | |
| 700 | 1 | |a Ciotti, Ana Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Sicurello, María Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Rios Leiva, Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Villalba, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Hortas, María |e verfasserin |4 aut | |
| 700 | 1 | |a Peña, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a González, Gabriela |e verfasserin |4 aut | |
| 700 | 1 | |a Zold, Camila Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Murer, Mario Gustavo |e verfasserin |4 aut | |
| 700 | 0 | |a EMSKC Group |e verfasserin |4 aut | |
| 700 | 1 | |a Grippo, M |e investigator |4 oth | |
| 700 | 1 | |a Vázquez, H |e investigator |4 oth | |
| 700 | 1 | |a Morós, C |e investigator |4 oth | |
| 700 | 1 | |a Di Santo, M |e investigator |4 oth | |
| 700 | 1 | |a Villa, A |e investigator |4 oth | |
| 700 | 1 | |a Lazota, P |e investigator |4 oth | |
| 700 | 1 | |a Foti, M |e investigator |4 oth | |
| 700 | 1 | |a Napoli, N |e investigator |4 oth | |
| 700 | 1 | |a Katsikas, M M |e investigator |4 oth | |
| 700 | 1 | |a Tonello, L |e investigator |4 oth | |
| 700 | 1 | |a Peña, J |e investigator |4 oth | |
| 700 | 1 | |a Etcheverry, M |e investigator |4 oth | |
| 700 | 1 | |a Iglesias, D |e investigator |4 oth | |
| 700 | 1 | |a Alcalde, A L |e investigator |4 oth | |
| 700 | 1 | |a Bruera, M J |e investigator |4 oth | |
| 700 | 1 | |a Bruzzo, V |e investigator |4 oth | |
| 700 | 1 | |a Giordano, P |e investigator |4 oth | |
| 700 | 1 | |a Pena Acero, F |e investigator |4 oth | |
| 700 | 1 | |a Netri Pelandi, G |e investigator |4 oth | |
| 700 | 1 | |a Pastaro, D |e investigator |4 oth | |
| 700 | 1 | |a Bleiz, J |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, M F |e investigator |4 oth | |
| 700 | 1 | |a Laghezza, L |e investigator |4 oth | |
| 700 | 1 | |a Molina, M B |e investigator |4 oth | |
| 700 | 1 | |a Patynok, N |e investigator |4 oth | |
| 700 | 1 | |a Chatelain, M S |e investigator |4 oth | |
| 700 | 1 | |a Aguilar, M J |e investigator |4 oth | |
| 700 | 1 | |a Gamboa, J |e investigator |4 oth | |
| 700 | 1 | |a Cervan, M |e investigator |4 oth | |
| 700 | 1 | |a Ruggeri, A |e investigator |4 oth | |
| 700 | 1 | |a Marinelli, I |e investigator |4 oth | |
| 700 | 1 | |a Checcacci, E |e investigator |4 oth | |
| 700 | 1 | |a Meregalli, C |e investigator |4 oth | |
| 700 | 1 | |a Damksy Barbosa, J |e investigator |4 oth | |
| 700 | 1 | |a Fernie, L |e investigator |4 oth | |
| 700 | 1 | |a Fernández, M J |e investigator |4 oth | |
| 700 | 1 | |a Saenz Tejeira, M M |e investigator |4 oth | |
| 700 | 1 | |a Cereigido, C |e investigator |4 oth | |
| 700 | 1 | |a Nunell, A |e investigator |4 oth | |
| 700 | 1 | |a Villar, D |e investigator |4 oth | |
| 700 | 1 | |a Mansilla, A D |e investigator |4 oth | |
| 700 | 1 | |a Darduin, M D |e investigator |4 oth | |
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