First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant
Copyright © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved..
INTRODUCTION: A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant.
MATERIAL AND METHODS: We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing.
RESULTS: We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations.
CONCLUSION: The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Enfermedades infecciosas y microbiologia clinica (English ed.) - 40(2022), 10 vom: 15. Dez., Seite 546-549 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
B.1.1.7 |
|---|
| Anmerkungen: |
Date Completed 06.12.2022 Date Revised 13.12.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.eimce.2021.02.013 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349769850 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349769850 | ||
| 003 | DE-627 | ||
| 005 | 20231226043421.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eimce.2021.02.013 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1165.xml |
| 035 | |a (DE-627)NLM349769850 | ||
| 035 | |a (NLM)36464472 | ||
| 035 | |a (PII)S2529-993X(22)00236-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Buenestado-Serrano, Sergio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.12.2022 | ||
| 500 | |a Date Revised 13.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION: A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant | ||
| 520 | |a MATERIAL AND METHODS: We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing | ||
| 520 | |a RESULTS: We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations | ||
| 520 | |a CONCLUSION: The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a B.1.1.7 | |
| 650 | 4 | |a B.1.1.7, Importación | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Importation | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Transmisión | |
| 650 | 4 | |a Transmission | |
| 650 | 4 | |a WGS | |
| 700 | 1 | |a Recio, Raúl |e verfasserin |4 aut | |
| 700 | 1 | |a Sola Campoy, Pedro J |e verfasserin |4 aut | |
| 700 | 1 | |a Catalán, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Folgueira, M Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Villa, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz Gallego, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a de la Cueva, Víctor Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Meléndez, M Angeles |e verfasserin |4 aut | |
| 700 | 1 | |a Andrés Zayas, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Losa-García, Juan E |e verfasserin |4 aut | |
| 700 | 1 | |a Goyanes, M José |e verfasserin |4 aut | |
| 700 | 1 | |a Fraile Torres, Arturo |e verfasserin |4 aut | |
| 700 | 1 | |a Von Wermitz, Andres |e verfasserin |4 aut | |
| 700 | 1 | |a Fradejas-Villajos, Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Del Arco, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Campelo-Gutiérrez, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a González Bodi, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a López-Wolf, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Iglesias-Franco, Higinio |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Lago, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Arce Arnaez, Araceli |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez Baena, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Ordobas Gavin, María |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Cardeñoso, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Viedma, Esther |e verfasserin |4 aut | |
| 700 | 1 | |a García de Viedma, Darío |e verfasserin |4 aut | |
| 700 | 0 | |a Gregorio Marañón Microbiology-ID COVID 19 Study Group, 12 de Octubre Microbiology COVID 19 Study Group, La Princesa Microbiology-ID COVID 19 Study Group, Hospital Alcorcón Microbiology-ID COVID 19 Group |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Enfermedades infecciosas y microbiologia clinica (English ed.) |d 2012 |g 40(2022), 10 vom: 15. Dez., Seite 546-549 |w (DE-627)NLM220666776 |x 2529-993X |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2022 |g number:10 |g day:15 |g month:12 |g pages:546-549 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.eimce.2021.02.013 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2022 |e 10 |b 15 |c 12 |h 546-549 | ||