Recent insight into autophagy and immunity at the maternal-fetal interface
Copyright © 2022 Elsevier B.V. All rights reserved..
Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
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| Enthalten in: |
Journal of reproductive immunology - 155(2023) vom: 01. Feb., Seite 103781 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Yuanyao [VerfasserIn] |
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| Links: |
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| Themen: |
Adaptive immunity |
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| Anmerkungen: |
Date Completed 20.01.2023 Date Revised 02.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jri.2022.103781 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349763275 |
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| 500 | |a Date Revised 02.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier B.V. All rights reserved. | ||
| 520 | |a Autophagy is a lysosomal degradation pathway that supports metabolic adaptation and energy cycling. It is essential for cell homeostasis, differentiation, development, and survival. Recent studies have shown that autophagy could influence immune responses by regulating immune cell functions. Reciprocally, immune cells strongly influence autophagy. Immune cells at the maternal-fetal interface are thought to play essential roles in pregnancy. Here, we review the induction of autophagy at the maternal-fetal interface and its role in decidualization and placental development. Additionally, we emphasize the role of autophagy in the immune microenvironment at the maternal-fetal interface, including innate immunity, adaptive immunity, and immune tolerance molecules. It also suggests new research directions and prospects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Autophagy | |
| 650 | 4 | |a adaptive immunity | |
| 650 | 4 | |a immune tolerance molecules | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a maternal-fetal interface | |
| 700 | 1 | |a Xiao, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jingming |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zhiquan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Huiping |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Shibin |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Surendra |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Aihua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chunyan |e verfasserin |4 aut | |
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