Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients
© 2022 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd..
BACKGROUND: Hypertension management in older patients represents a challenge, particularly when hospitalized.
OBJECTIVE: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients.
METHODS: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge.
RESULTS: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death.
CONCLUSIONS: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
European journal of clinical investigation - 53(2023), 4 vom: 10. Apr., Seite e13931 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cicco, Sebastiano [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 17.03.2023 Date Revised 17.03.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/eci.13931 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349666075 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349666075 | ||
| 003 | DE-627 | ||
| 005 | 20231226043154.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/eci.13931 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1165.xml |
| 035 | |a (DE-627)NLM349666075 | ||
| 035 | |a (NLM)36453932 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cicco, Sebastiano |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.03.2023 | ||
| 500 | |a Date Revised 17.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Hypertension management in older patients represents a challenge, particularly when hospitalized | ||
| 520 | |a OBJECTIVE: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients | ||
| 520 | |a METHODS: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge | ||
| 520 | |a RESULTS: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death | ||
| 520 | |a CONCLUSIONS: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a antihypertensive drugs | |
| 650 | 4 | |a cardiovascular events | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a older patients | |
| 650 | 4 | |a survival | |
| 650 | 7 | |a Angiotensin Receptor Antagonists |2 NLM | |
| 650 | 7 | |a Angiotensin-Converting Enzyme Inhibitors |2 NLM | |
| 650 | 7 | |a Angiotensins |2 NLM | |
| 650 | 7 | |a Antihypertensive Agents |2 NLM | |
| 650 | 7 | |a Calcium Channel Blockers |2 NLM | |
| 650 | 7 | |a Sodium Chloride Symporter Inhibitors |2 NLM | |
| 700 | 1 | |a D Abbondanza, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Proietti, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Zaccone, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Pes, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Caradio, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Mattioli, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Piano, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Marra, Alberto Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Nobili, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Mannucci, Pier Mannuccio |e verfasserin |4 aut | |
| 700 | 1 | |a Pietrangelo, Antonello |e verfasserin |4 aut | |
| 700 | 1 | |a Sesti, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Buzzetti, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Salzano, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Cimellaro, Antonio |e verfasserin |4 aut | |
| 700 | 0 | |a Giovani Internisti Società Italiana di Medicina Interna (GIS-SIMI) and of the REPOSI Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Mannucci, Pier Mannuccio |e investigator |4 oth | |
| 700 | 1 | |a Nobili, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Sesti, Giorgio |e investigator |4 oth | |
| 700 | 1 | |a Pietrangelo, Antonello |e investigator |4 oth | |
| 700 | 1 | |a Perticone, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Violi, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Corazza, Gino Roberto |e investigator |4 oth | |
| 700 | 1 | |a Corrao, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Marengoni, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Salerno, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Cesari, Matteo |e investigator |4 oth | |
| 700 | 1 | |a Tettamanti, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Pasina, Luca |e investigator |4 oth | |
| 700 | 1 | |a Franchi, Carlotta |e investigator |4 oth | |
| 700 | 1 | |a Franchi, Carlotta |e investigator |4 oth | |
| 700 | 1 | |a Novella, Alessio |e investigator |4 oth | |
| 700 | 1 | |a Tettamanti, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Miglio, Gabriella |e investigator |4 oth | |
| 700 | 1 | |a Tettamanti, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Galbussera, Alessia Antonella |e investigator |4 oth | |
| 700 | 1 | |a Ardoino, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Novella, Alessio |e investigator |4 oth | |
| 700 | 1 | |a Prisco, Domenico |e investigator |4 oth | |
| 700 | 1 | |a Silvestri, Elena |e investigator |4 oth | |
| 700 | 1 | |a Emmi, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Bettiol, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Mattioli, Irene |e investigator |4 oth | |
| 700 | 1 | |a Biolo, Gianni |e investigator |4 oth | |
| 700 | 1 | |a Zanetti, Michela |e investigator |4 oth | |
| 700 | 1 | |a Bartelloni, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Zaccari, Michele |e investigator |4 oth | |
| 700 | 1 | |a Chiuch, Massimiliano |e investigator |4 oth | |
| 700 | 1 | |a Vanoli, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Grignani, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Pulixi, Edoardo Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Pirro, Matteo |e investigator |4 oth | |
| 700 | 1 | |a Lupattelli, Graziana |e investigator |4 oth | |
| 700 | 1 | |a Bianconi, Vanessa |e investigator |4 oth | |
| 700 | 1 | |a Alcidi, Riccardo |e investigator |4 oth | |
| 700 | 1 | |a Giotta, Alessia |e investigator |4 oth | |
| 700 | 1 | |a Mannarino, Massimo R |e investigator |4 oth | |
| 700 | 1 | |a Girelli, Domenico |e investigator |4 oth | |
| 700 | 1 | |a Busti, Fabiana |e investigator |4 oth | |
| 700 | 1 | |a Marchi, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Barbagallo, Mario |e investigator |4 oth | |
| 700 | 1 | |a Dominguez, Ligia |e investigator |4 oth | |
| 700 | 1 | |a Beneduce, Vincenza |e investigator |4 oth | |
| 700 | 1 | |a Cacioppo, Federica |e investigator |4 oth | |
| 700 | 1 | |a Corrao, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Natoli, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Mularo, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Raspanti, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Argano, Christiano |e investigator |4 oth | |
| 700 | 1 | |a Cavallaro, Federica |e investigator |4 oth | |
| 700 | 1 | |a Zoli, Marco |e investigator |4 oth | |
| 700 | 1 | |a Matacena, Maria Laura |e investigator |4 oth | |
| 700 | 1 | |a Orio, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Magnolfi, Eleonora |e investigator |4 oth | |
| 700 | 1 | |a Serafini, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Simili, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Brunori, Mattia |e investigator |4 oth | |
| 700 | 1 | |a Lazzari, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Simili, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Cappellini, Maria Domenica |e investigator |4 oth | |
| 700 | 1 | |a Fabio, Giovanna |e investigator |4 oth | |
| 700 | 1 | |a De Amicis, Margherita Migone |e investigator |4 oth | |
| 700 | 1 | |a De Luca, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Scaramellini, Natalia |e investigator |4 oth | |
| 700 | 1 | |a Di Stefano, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Leoni, Simona |e investigator |4 oth | |
| 700 | 1 | |a Seghezzi, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Di Mauro, Alessandra Danuto |e investigator |4 oth | |
| 700 | 1 | |a Maira, Diletta |e investigator |4 oth | |
| 700 | 1 | |a Mancarella, Marta |e investigator |4 oth | |
| 700 | 1 | |a Lucchi, Tiziano |e investigator |4 oth | |
| 700 | 1 | |a Rossi, Paolo Dionigi |e investigator |4 oth | |
| 700 | 1 | |a Clerici, Marta |e investigator |4 oth | |
| 700 | 1 | |a Leoni, Simona |e investigator |4 oth | |
| 700 | 1 | |a Di Mauro, Alessandra Danuta |e investigator |4 oth | |
| 700 | 1 | |a Bonini, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Conti, Federica |e investigator |4 oth | |
| 700 | 1 | |a Prolo, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Fabrizi, Maddalena |e investigator |4 oth | |
| 700 | 1 | |a Martelengo, Miriana |e investigator |4 oth | |
| 700 | 1 | |a Vigani, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Di Sabatino, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Miceli, Emanuela |e investigator |4 oth | |
| 700 | 1 | |a Lenti, Marco Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Pisati, Martina |e investigator |4 oth | |
| 700 | 1 | |a Pitotti, Lavinia |e investigator |4 oth | |
| 700 | 1 | |a Padula, Donatella |e investigator |4 oth | |
| 700 | 1 | |a Antoci, Valentina |e investigator |4 oth | |
| 700 | 1 | |a Cambiè, Ginevra |e investigator |4 oth | |
| 700 | 1 | |a Pontremoli, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Beccati, Valentina |e investigator |4 oth | |
| 700 | 1 | |a Nobili, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Leoncini, Giovanna |e investigator |4 oth | |
| 700 | 1 | |a Alberto, Jacopo |e investigator |4 oth | |
| 700 | 1 | |a Cattaneo, Federico |e investigator |4 oth | |
| 700 | 1 | |a Anastasio, Luigi |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical investigation |d 1970 |g 53(2023), 4 vom: 10. Apr., Seite e13931 |w (DE-627)NLM000003107 |x 1365-2362 |7 nnns |
| 773 | 1 | 8 | |g volume:53 |g year:2023 |g number:4 |g day:10 |g month:04 |g pages:e13931 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/eci.13931 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 53 |j 2023 |e 4 |b 10 |c 04 |h e13931 | ||