Epidemiology of heart failure in young adults : a French nationwide cohort study
The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology..
AIMS: Heart failure (HF) in young adults is uncommon, and changes in its incidence and prognosis in recent years are poorly described.
METHODS AND RESULTS: The incidence and prognosis of HF in young adults (1850 years) were characterized using nationwide medico-administrative data from the French National Hospitalization Database (period 20132018). A total of 1,486 877 patients hospitalized for incident HF were identified, including 70 075 (4.7) patients aged 1850 years (estimated incidence of 0.44 for this age group). During the study period, the overall incidence of HF tended to decrease in the overall population but significantly increased by 0.041 in young adults (P 0.001). This increase was notably observed among young men (from 0.51 to 0.59, P 0.001), particularly those aged 3650 years. In these young men, ischaemic heart disease (IHD) was the most frequently reported cause of HF, whereas non-ischaemic HF was mainly observed in patients 35 years old. In contrast to non-ischaemic HF, the incidence of IHD increased over the study period, which suggests that IHD-related HF is progressively affecting younger patients. Concordantly, young HF patients presented with high rates of traditional IHD risk factors, including obesity, smoking, hypertension, dyslipidaemia, or diabetes. Lastly, the rates of re-hospitalization (for HF or for any cause) within two years after the first HF event and in-hospital mortality were high in all groups, indicating a poor-prognosis population.
CONCLUSION: Strategies for the prevention of HF risk factors should be strongly considered for patients under 50 years old.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
European heart journal - 44(2023), 5 vom: 01. Feb., Seite 383-392 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lecoeur, Emmanuel [VerfasserIn] |
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| Links: |
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| Themen: |
Epidemiology |
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| Anmerkungen: |
Date Completed 02.02.2023 Date Revised 27.03.2023 published: Print CommentIn: Eur Heart J. 2022 Dec 20;:. - PMID 36537120 Citation Status MEDLINE |
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| doi: |
10.1093/eurheartj/ehac651 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349656673 |
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| 245 | 1 | 0 | |a Epidemiology of heart failure in young adults |b a French nationwide cohort study |
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| 500 | |a Date Completed 02.02.2023 | ||
| 500 | |a Date Revised 27.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Eur Heart J. 2022 Dec 20;:. - PMID 36537120 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. | ||
| 520 | |a AIMS: Heart failure (HF) in young adults is uncommon, and changes in its incidence and prognosis in recent years are poorly described | ||
| 520 | |a METHODS AND RESULTS: The incidence and prognosis of HF in young adults (1850 years) were characterized using nationwide medico-administrative data from the French National Hospitalization Database (period 20132018). A total of 1,486 877 patients hospitalized for incident HF were identified, including 70 075 (4.7) patients aged 1850 years (estimated incidence of 0.44 for this age group). During the study period, the overall incidence of HF tended to decrease in the overall population but significantly increased by 0.041 in young adults (P 0.001). This increase was notably observed among young men (from 0.51 to 0.59, P 0.001), particularly those aged 3650 years. In these young men, ischaemic heart disease (IHD) was the most frequently reported cause of HF, whereas non-ischaemic HF was mainly observed in patients 35 years old. In contrast to non-ischaemic HF, the incidence of IHD increased over the study period, which suggests that IHD-related HF is progressively affecting younger patients. Concordantly, young HF patients presented with high rates of traditional IHD risk factors, including obesity, smoking, hypertension, dyslipidaemia, or diabetes. Lastly, the rates of re-hospitalization (for HF or for any cause) within two years after the first HF event and in-hospital mortality were high in all groups, indicating a poor-prognosis population | ||
| 520 | |a CONCLUSION: Strategies for the prevention of HF risk factors should be strongly considered for patients under 50 years old | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Ischaemia | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Young people | |
| 700 | 1 | |a Domeng, Orianne |e verfasserin |4 aut | |
| 700 | 1 | |a Fayol, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Jannot, Anne-Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Hulot, Jean-Sbastien |e verfasserin |4 aut | |
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