Long-Term Follow-Up on Bilateral Posterior Hypothalamic Deep Brain Stimulation for Treating Refractory Aggressive Behavior in a Patient with Cri du Chat Syndrome : Analysis of Clinical Data, Intraoperative Microdialysis, and Imaging Connectomics
© 2022 S. Karger AG, Basel..
Posterior hypothalamic-deep brain stimulation (pHyp-DBS) has been reported as a successful treatment for reducing refractory aggressive behaviors in patients with distinct primary diagnoses. Here, we report on a patient with cri du chat syndrome presenting severe self-injury and aggressive behaviors toward others, who was treated with pHyp-DBS. Positive results were observed at long-term follow-up in aggressive behavior and quality of life. Intraoperative microdialysis and imaging connectomics analysis were performed to investigate possible mechanisms of action. Our results suggest the involvement of limbic and motor areas and alterations in main neurotransmitter levels in the targeted area that are associated with positive results following treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:100 |
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| Enthalten in: |
Stereotactic and functional neurosurgery - 100(2022), 5-6 vom: 05., Seite 275-281 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
López Ríos, Adriana Lucia [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 18.01.2023 Date Revised 27.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000526871 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349591482 |
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| 245 | 1 | 0 | |a Long-Term Follow-Up on Bilateral Posterior Hypothalamic Deep Brain Stimulation for Treating Refractory Aggressive Behavior in a Patient with Cri du Chat Syndrome |b Analysis of Clinical Data, Intraoperative Microdialysis, and Imaging Connectomics |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 S. Karger AG, Basel. | ||
| 520 | |a Posterior hypothalamic-deep brain stimulation (pHyp-DBS) has been reported as a successful treatment for reducing refractory aggressive behaviors in patients with distinct primary diagnoses. Here, we report on a patient with cri du chat syndrome presenting severe self-injury and aggressive behaviors toward others, who was treated with pHyp-DBS. Positive results were observed at long-term follow-up in aggressive behavior and quality of life. Intraoperative microdialysis and imaging connectomics analysis were performed to investigate possible mechanisms of action. Our results suggest the involvement of limbic and motor areas and alterations in main neurotransmitter levels in the targeted area that are associated with positive results following treatment | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cri du chat syndrome | |
| 650 | 4 | |a Deep brain stimulation | |
| 650 | 4 | |a Imaging connectomics | |
| 650 | 4 | |a Intraoperative microdialysis | |
| 650 | 4 | |a Posterior hypothalamus | |
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| 700 | 1 | |a Hutchison, William D |e verfasserin |4 aut | |
| 700 | 1 | |a Botero Posada, Luis Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Ahunca Velasquez, Luisa Fernanda |e verfasserin |4 aut | |
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| 700 | 1 | |a Gloria Escobar, José Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Chacon Ruiz Martinez, Raquel |e verfasserin |4 aut | |
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| 700 | 1 | |a Restrepo Bravo, Carlos Anibal |e verfasserin |4 aut | |
| 700 | 1 | |a Gouveia, Flavia Venetucci |e verfasserin |4 aut | |
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