Current Drug Delivery Strategies for Buccal Cavity Ailments using Mouth Dissolving Wafer Technology : A Comprehensive Review on the Present State of the Art

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BACKGROUND: Mouth-dissolving wafer is polymer-based matrice that incorporates various pharmaceutical agents for oral drug delivery. This polymeric wafer is ingenious in the way that it needs not be administered with water, like in conventional tablet dosage form. It has better compliance among the pediatric and geriatric groups owing to its ease of administration.

OBJECTIVE: The polymeric wafer dissolves quickly in the oral cavity and is highly effective for a targeted local effect in buccal-specific ailments. It is a safe, effective, and versatile drug delivery carrier for a range of drugs used to treat a plethora of oral cavity-specific ailments that inflict common people, like thrush, canker sores, periodontal disease, benign oral cavity tumors, buccal neoplasm, and malignancies. This review paper focuses thoroughly on the present state of the art in mouth-dissolving wafer technology for buccal drug delivery and targeting. Moreover, we have also addressed present-time limitations associated with wafer technology to aid researchers in future developments in the arena of buccal drug delivery.

CONCLUSION: This dynamic novel formulation has tremendous future implications for designing drug delivery systems to target pernicious ailments and diseases specific to the buccal mucosa. In a nutshell, this review paper aims to summarize the present state of the art in buccal targeted drug delivery.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

2023

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:21

Enthalten in:

Current drug delivery - 21(2023), 3 vom: 28., Seite 339-359

Sprache:

Englisch

Beteiligte Personen:

Jana, Bani Kumar [VerfasserIn]
Singh, Mohini [VerfasserIn]
Dutta, Rajat Subhra [VerfasserIn]
Mazumder, Bhaskar [VerfasserIn]

Links:

Volltext

Themen:

Buccal cavity ailments
Drug Carriers
Erythroplakia and leukoplakia
Journal Article
Mouth dissolving wafers
Mucoepidermoid carcinoma
Oral administration
Oral thrush.
Polymers
Review
Squamous cell carcinomas
Trans-mucosal route

Anmerkungen:

Date Completed 23.11.2023

Date Revised 23.11.2023

published: Print

Citation Status MEDLINE

doi:

10.2174/1567201820666221128152010

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM349568308