Genistein Effects on Various Human Disorders Mediated via Nrf2 Signaling
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Genistein is a flavonoid, mostly found in soybean extract and is widely used for its antioxidant and anti-inflammatory activities. Genistein can interact with estrogen receptors due to its structural similarities to estrogen. It also inhibits protein tyrosine kinases and affects a variety of intracellular signal transductions. Genistein attenuates oxidative stress via diverse cellular mechanisms. However, nuclear factor (erythroidderived 2)-like 2 (Nrf2), the main antioxidant regulator, potentiates genistein's antioxidant effects and reduces cell damage. Nrf2 includes of seven domains and controls the expression of the phase II antioxidant enzymes to decrease oxidative stress. In this review, we address findings related to Nrf2 signaling pathways in the context of genistein's effects on diverse human diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Current molecular medicine - 24(2024), 1 vom: 20., Seite 40-50 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Shirvanian, Kasra [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antioxidant. |
|---|
| Anmerkungen: |
Date Completed 11.01.2024 Date Revised 11.01.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1566524023666221128162753 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349568197 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349568197 | ||
| 003 | DE-627 | ||
| 005 | 20240114233713.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1566524023666221128162753 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1256.xml |
| 035 | |a (DE-627)NLM349568197 | ||
| 035 | |a (NLM)36443970 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Shirvanian, Kasra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genistein Effects on Various Human Disorders Mediated via Nrf2 Signaling |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.01.2024 | ||
| 500 | |a Date Revised 11.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a Genistein is a flavonoid, mostly found in soybean extract and is widely used for its antioxidant and anti-inflammatory activities. Genistein can interact with estrogen receptors due to its structural similarities to estrogen. It also inhibits protein tyrosine kinases and affects a variety of intracellular signal transductions. Genistein attenuates oxidative stress via diverse cellular mechanisms. However, nuclear factor (erythroidderived 2)-like 2 (Nrf2), the main antioxidant regulator, potentiates genistein's antioxidant effects and reduces cell damage. Nrf2 includes of seven domains and controls the expression of the phase II antioxidant enzymes to decrease oxidative stress. In this review, we address findings related to Nrf2 signaling pathways in the context of genistein's effects on diverse human diseases | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Genistein | |
| 650 | 4 | |a Nrf2 signaling | |
| 650 | 4 | |a antioxidant. | |
| 650 | 4 | |a isoflavone | |
| 650 | 4 | |a nuclear factor erythroid 2-related factor 2 | |
| 650 | 4 | |a oxidative stress | |
| 650 | 7 | |a Genistein |2 NLM | |
| 650 | 7 | |a DH2M523P0H |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a NF-E2-Related Factor 2 |2 NLM | |
| 700 | 1 | |a Vali, Reyhaneh |e verfasserin |4 aut | |
| 700 | 1 | |a Farkhondeh, Tahereh |e verfasserin |4 aut | |
| 700 | 1 | |a Abderam, Amir |e verfasserin |4 aut | |
| 700 | 1 | |a Aschner, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Samarghandian, Saeed |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current molecular medicine |d 2001 |g 24(2024), 1 vom: 20., Seite 40-50 |w (DE-627)NLM117823937 |x 1875-5666 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2024 |g number:1 |g day:20 |g pages:40-50 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1566524023666221128162753 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2024 |e 1 |b 20 |h 40-50 | ||