Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China

H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and pathogenic features of this subtype. During 2000-2021, H6 subtype AIVs spread widely through Southern China and presented high host diversity. On analysing 171 H6 viruses isolated during 2009-2021, dynamic reassortments were observed among H6 and other co-circulating AIV subtypes, and these generated a total of 16 different genotypes. A few H6N6 strains possessed L226 and S228 mutations of hemagglutinin (H3 numbering), which may enhance the affinity of H6 viruses to human receptors. H6N6 viruses also exhibited divergent pathogenicity and growth profiles in vivo and in vitro. Some of the H6N6 viruses could infect mice without mammalian adaptation, and even caused death in this species. Therefore, our study demonstrated that the H6 AIVs posed a potential threat to human health and highlighted the urgent need for continued surveillance and evaluation of the H6 influenza viruses circulating in the field.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Emerging microbes & infections - 12(2023), 1 vom: 06. Dez., Seite 2151380

Sprache:

Englisch

Beteiligte Personen:

Xu, Xiaohao [VerfasserIn]
Chen, Qi [VerfasserIn]
Tan, Min [VerfasserIn]
Liu, Jia [VerfasserIn]
Li, Xiyan [VerfasserIn]
Yang, Lei [VerfasserIn]
Shu, Yuelong [VerfasserIn]
Wang, Dayan [VerfasserIn]
Zhu, Wenfei [VerfasserIn]

Links:

Volltext

Themen:

Epidemiology
Evolution
H6 avian influenza viruses
Journal Article
Pathogenicity

Anmerkungen:

Date Completed 22.12.2022

Date Revised 27.12.2022

published: Print

Citation Status MEDLINE

doi:

10.1080/22221751.2022.2151380

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM349533849