Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory
Copyright © 2022 Li, Hu, Zhang, Zhao, Liu, Chen and Chen..
Reconsolidation of heroin-associated memory is an independent memory process that occurs following retrieval, which is essential for the sustained capacity of an associative drug stimulus to precipitate heroin-seeking. Extracellular signal-regulated kinase (ERK) in the basolateral amygdala (BLA) mediates the reconsolidation of drug memory. In the present study, we utilized a rat model of drug craving and relapse to verify the hypothesis that the reconsolidation of heroin-associated memory requires ERK in an instrumental heroin-seeking behavior, focusing on the BLA brain region, which is crucial for synaptic plasticity and memory processes. We found that bilateral intra-BLA infusions of U0126 (1 μg/0.5 μl), an ERK inhibitor, immediately after retrieving heroin-associated memory significantly reduced cue-induced and drug-induced reinstatement and spontaneous recovery of heroin-seeking compared to the vehicle. Furthermore, this inhibitory effect was related to the characteristic of reconsolidation. Conversely, no effect was observed on the heroin-seeking behavior when the intra-BLA infusion of U0126 was administered 6 h after the heroin-associated memory retrieval or without memory retrieval. Together, these data suggest that disrupting the reconsolidation of heroin-associated memory via an ERK inhibitor may serve as a promising option for treating relapse in opiate addicts.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
---|---|
Enthalten in: |
Frontiers in molecular neuroscience - 15(2022) vom: 15., Seite 1020098 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Haoyu [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 29.11.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3389/fnmol.2022.1020098 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM349510849 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM349510849 | ||
003 | DE-627 | ||
005 | 20231226042810.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fnmol.2022.1020098 |2 doi | |
028 | 5 | 2 | |a pubmed24n1164.xml |
035 | |a (DE-627)NLM349510849 | ||
035 | |a (NLM)36438183 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Haoyu |e verfasserin |4 aut | |
245 | 1 | 0 | |a Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 29.11.2022 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a Copyright © 2022 Li, Hu, Zhang, Zhao, Liu, Chen and Chen. | ||
520 | |a Reconsolidation of heroin-associated memory is an independent memory process that occurs following retrieval, which is essential for the sustained capacity of an associative drug stimulus to precipitate heroin-seeking. Extracellular signal-regulated kinase (ERK) in the basolateral amygdala (BLA) mediates the reconsolidation of drug memory. In the present study, we utilized a rat model of drug craving and relapse to verify the hypothesis that the reconsolidation of heroin-associated memory requires ERK in an instrumental heroin-seeking behavior, focusing on the BLA brain region, which is crucial for synaptic plasticity and memory processes. We found that bilateral intra-BLA infusions of U0126 (1 μg/0.5 μl), an ERK inhibitor, immediately after retrieving heroin-associated memory significantly reduced cue-induced and drug-induced reinstatement and spontaneous recovery of heroin-seeking compared to the vehicle. Furthermore, this inhibitory effect was related to the characteristic of reconsolidation. Conversely, no effect was observed on the heroin-seeking behavior when the intra-BLA infusion of U0126 was administered 6 h after the heroin-associated memory retrieval or without memory retrieval. Together, these data suggest that disrupting the reconsolidation of heroin-associated memory via an ERK inhibitor may serve as a promising option for treating relapse in opiate addicts | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a BLA | |
650 | 4 | |a ERK | |
650 | 4 | |a heroin | |
650 | 4 | |a reconsolidation | |
650 | 4 | |a relapse | |
700 | 1 | |a Hu, Ting |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Yanghui |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Zijin |e verfasserin |4 aut | |
700 | 1 | |a Liu, Qing |e verfasserin |4 aut | |
700 | 1 | |a Chen, Zihua |e verfasserin |4 aut | |
700 | 1 | |a Chen, Si |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Frontiers in molecular neuroscience |d 2008 |g 15(2022) vom: 15., Seite 1020098 |w (DE-627)NLM183921038 |x 1662-5099 |7 nnns |
773 | 1 | 8 | |g volume:15 |g year:2022 |g day:15 |g pages:1020098 |
856 | 4 | 0 | |u http://dx.doi.org/10.3389/fnmol.2022.1020098 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 15 |j 2022 |b 15 |h 1020098 |