Hyperandrogen-induced polyol pathway flux increase affects ovarian function in polycystic ovary syndrome via excessive oxidative stress
Copyright © 2022. Published by Elsevier Inc..
AIMS: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in the women of childbearing age. It is characterized by hyperandrogenism and abnormal follicular growth and ovulation. The polyol pathway is a glucose metabolism bypass pathway initiated by aldose reductase (ADR). Androgen induces the expression of ADR in the male reproductive tract, which has a general physiological significance for male reproductive function. Here we investigate whether hyperandrogenemia in PCOS leads to increased flux of the polyol pathway in ovarian tissue, which in turn affects follicular maturation and ovulation through oxidative stress.
MAIN METHODS: We used clinical epidemiological methods to collect serum and granulosa cells from clinical subjects for a clinical case-control study. At the same time, cell biology and molecular biology techniques were used to conduct animal and cell experiments to further explore the mechanism of hyperandrogen-induced ovarian polyol pathway hyperactivity and damage to ovarian function.
KEY FINDINGS: Here, we find that hyperandrogenism of PCOS can induce the expression of ovarian aldose reductase, which leads to the increase of the polyol pathway flux, and affects ovarian function through excessive oxidative stress.
SIGNIFICANCE: Our research has enriched the pathological mechanism of PCOS and may provide a new clue for the clinical treatment of PCOS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:313 |
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| Enthalten in: |
Life sciences - 313(2023) vom: 15. Jan., Seite 121224 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Yi-Cheng [VerfasserIn] |
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| Links: |
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| Themen: |
Aldehyde Reductase |
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| Anmerkungen: |
Date Completed 03.01.2023 Date Revised 11.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.lfs.2022.121224 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349481350 |
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| 100 | 1 | |a Wang, Yi-Cheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hyperandrogen-induced polyol pathway flux increase affects ovarian function in polycystic ovary syndrome via excessive oxidative stress |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 03.01.2023 | ||
| 500 | |a Date Revised 11.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022. Published by Elsevier Inc. | ||
| 520 | |a AIMS: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in the women of childbearing age. It is characterized by hyperandrogenism and abnormal follicular growth and ovulation. The polyol pathway is a glucose metabolism bypass pathway initiated by aldose reductase (ADR). Androgen induces the expression of ADR in the male reproductive tract, which has a general physiological significance for male reproductive function. Here we investigate whether hyperandrogenemia in PCOS leads to increased flux of the polyol pathway in ovarian tissue, which in turn affects follicular maturation and ovulation through oxidative stress | ||
| 520 | |a MAIN METHODS: We used clinical epidemiological methods to collect serum and granulosa cells from clinical subjects for a clinical case-control study. At the same time, cell biology and molecular biology techniques were used to conduct animal and cell experiments to further explore the mechanism of hyperandrogen-induced ovarian polyol pathway hyperactivity and damage to ovarian function | ||
| 520 | |a KEY FINDINGS: Here, we find that hyperandrogenism of PCOS can induce the expression of ovarian aldose reductase, which leads to the increase of the polyol pathway flux, and affects ovarian function through excessive oxidative stress | ||
| 520 | |a SIGNIFICANCE: Our research has enriched the pathological mechanism of PCOS and may provide a new clue for the clinical treatment of PCOS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aldose reductase | |
| 650 | 4 | |a Follicular growth | |
| 650 | 4 | |a Hyperandrogenism | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Polycystic ovary syndrome | |
| 650 | 4 | |a Polyol pathway | |
| 650 | 7 | |a polyol |2 NLM | |
| 650 | 7 | |a Aldehyde Reductase |2 NLM | |
| 650 | 7 | |a EC 1.1.1.21 |2 NLM | |
| 700 | 1 | |a Ma, Yong-Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Zhi-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xue-Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Li-Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Wen-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Tu, Sha-Sha |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Dong-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jin-Hu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Bing-Kun |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Liang-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Qiong-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yue, Li-Min |e verfasserin |4 aut | |
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