Survival outcomes for patients with T3N0M0 squamous cell carcinoma of the glottis treated with definitive radiation alone versus chemoradiation
© 2022 Wiley Periodicals LLC..
BACKGROUND: Given the poor lymphatics of the glottis, we evaluated omission of chemotherapy in patients treated definitely for T3N0M0 squamous cell carcinoma (SCC) of the glottis.
METHODS: We performed survival analysis of patients with T3N0M0 SCC of the glottis identified in the National Cancer Database treated with radiation alone versus chemoradiation.
RESULTS: A total of 3785 patients were identified. Patients age ≥70 and those with comorbidities were less likely to receive chemotherapy (odds ratio [OR] 0.30, 95% CI [0.25-0.37] and 0.48 [0.31-0.76], respectively). Five-year OS was lower in patients treated with radiation versus chemoradiation (33.8% [30.3%-37.2%] vs. 58.0% [55.8%-60.0%]). In patients <70 with no comorbidities this difference persisted (51.0% [44.5%-57.0%] versus 66.7% [64.0%-69.3%]).
CONCLUSION: Overall survival was higher in patients treated with chemoradiation compared to radiation alone, even when controlling for age and comorbidities. Radiotherapy with chemotherapy omission is not appropriate in patients with T3N0M0 SCC of the glottis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Head & neck - 45(2023), 2 vom: 06. Feb., Seite 431-438 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rock, Calvin B [VerfasserIn] |
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| Links: |
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| Themen: |
Chemoradiation |
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| Anmerkungen: |
Date Completed 03.01.2023 Date Revised 16.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hed.27255 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349466750 |
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| 245 | 1 | 0 | |a Survival outcomes for patients with T3N0M0 squamous cell carcinoma of the glottis treated with definitive radiation alone versus chemoradiation |
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| 500 | |a Date Revised 16.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Given the poor lymphatics of the glottis, we evaluated omission of chemotherapy in patients treated definitely for T3N0M0 squamous cell carcinoma (SCC) of the glottis | ||
| 520 | |a METHODS: We performed survival analysis of patients with T3N0M0 SCC of the glottis identified in the National Cancer Database treated with radiation alone versus chemoradiation | ||
| 520 | |a RESULTS: A total of 3785 patients were identified. Patients age ≥70 and those with comorbidities were less likely to receive chemotherapy (odds ratio [OR] 0.30, 95% CI [0.25-0.37] and 0.48 [0.31-0.76], respectively). Five-year OS was lower in patients treated with radiation versus chemoradiation (33.8% [30.3%-37.2%] vs. 58.0% [55.8%-60.0%]). In patients <70 with no comorbidities this difference persisted (51.0% [44.5%-57.0%] versus 66.7% [64.0%-69.3%]) | ||
| 520 | |a CONCLUSION: Overall survival was higher in patients treated with chemoradiation compared to radiation alone, even when controlling for age and comorbidities. Radiotherapy with chemotherapy omission is not appropriate in patients with T3N0M0 SCC of the glottis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a chemoradiation | |
| 650 | 4 | |a glottis | |
| 650 | 4 | |a head and neck cancer | |
| 650 | 4 | |a larynx | |
| 650 | 4 | |a oral cancer | |
| 650 | 4 | |a radiation | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Hutten, Ryan J |e verfasserin |4 aut | |
| 700 | 1 | |a Weil, Chris R |e verfasserin |4 aut | |
| 700 | 1 | |a Lloyd, Shane |e verfasserin |4 aut | |
| 700 | 1 | |a Kerrigan, Kathleen C |e verfasserin |4 aut | |
| 700 | 1 | |a Cannon, Richard B |e verfasserin |4 aut | |
| 700 | 1 | |a Hitchcock, Ying J |e verfasserin |4 aut | |
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