Distinct T cell subsets in adipose tissue are associated with obesity
© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH..
Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data on human adipose tissue T cells in obesity are limited, reflected by the lack of phenotypic markers to define tissue-resident T cell subsets. In this study, we performed a deep characterization of T cells in blood and adipose tissue depots using multicolor flow cytometry and RNA sequencing. We identified distinct subsets of T cells associated with obesity expressing the activation markers, CD26 and CCR5, and obesity-specific genes that are potentially engaged in activating pro-inflammatory pathway, including ceramide signaling, autophagy, and IL-6 signaling. These findings increase our knowledge on the heterogeneity of T cells in adipose tissue and on subsets that may play a role in obesity-related pathogenesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
European journal of immunology - 53(2023), 2 vom: 03. Feb., Seite e2249990 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Haugstøyl, Martha E [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.02.2023 Date Revised 19.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/eji.202249990 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data on human adipose tissue T cells in obesity are limited, reflected by the lack of phenotypic markers to define tissue-resident T cell subsets. In this study, we performed a deep characterization of T cells in blood and adipose tissue depots using multicolor flow cytometry and RNA sequencing. We identified distinct subsets of T cells associated with obesity expressing the activation markers, CD26 and CCR5, and obesity-specific genes that are potentially engaged in activating pro-inflammatory pathway, including ceramide signaling, autophagy, and IL-6 signaling. These findings increase our knowledge on the heterogeneity of T cells in adipose tissue and on subsets that may play a role in obesity-related pathogenesis | ||
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| 700 | 1 | |a Strand, Kristina |e verfasserin |4 aut | |
| 700 | 1 | |a Stiglund, Natalie |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Lawrence-Archer, Laurence |e verfasserin |4 aut | |
| 700 | 1 | |a Hjellestad, Iren D |e verfasserin |4 aut | |
| 700 | 1 | |a Sparrelid, Ernesto |e verfasserin |4 aut | |
| 700 | 1 | |a Busch, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Hjelmesaeth, Jøran |e verfasserin |4 aut | |
| 700 | 1 | |a Hertel, Jens K |e verfasserin |4 aut | |
| 700 | 1 | |a Ponzetta, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Mellgren, Gunnar |e verfasserin |4 aut | |
| 700 | 1 | |a Fernø, Johan |e verfasserin |4 aut | |
| 700 | 1 | |a Björkström, Niklas K |e verfasserin |4 aut | |
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