The post-VTE functional status scale for assessment of functional limitations in patients with venous thromboembolism : Construct validity and responsiveness in a prospective cohort study
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: A large proportion of patients experience functional limitations after an acute episode of venous thromboembolism (VTE). Recently, the post-VTE functional status (PVFS) scale was proposed to capture these limitations. We performed a prospective cohort study to validate this scale.
METHODS: The PVFS scale, PROMIS physical function 10a, EQ-5D-5L, and disease-specific quality of life (VEINES-QOL/Sym, PEmb-QoL) were assessed within three weeks of VTE diagnosis and after a median (IQR) follow-up of 13.4 (12.7-15.9) weeks. To evaluate construct validity of the PVFS scale, we determined correlations of PVFS scale with the other health measurements and investigated differences in patients above/below 70 years. Responsiveness was evaluated with a linear regression model, predicting change in PROMIS with change in PVFS scale.
RESULTS: We included 211 patients (median (IQR) age: 55.1 (44.1-67.6) years, 40 % women). Pulmonary embolism was diagnosed in 105 (49.8 %) patients and 62.6 % of events were unprovoked. The PVFS scale correlated with PROMIS physical function (Spearman's rho (r): -0.67 and -0.63, p < 0.001) and EQ-5D-5L index (r = -0.61 and -0.61, p < 0.001) at baseline and follow-up. Furthermore, PVFS correlated moderately to strongly with disease-specific quality of life. Patients >70 years had significantly higher PVFS grades at follow-up (median (IQR): 2 (0-3) vs. 1 (0-2), p = 0.010). Changes in PVFS scale over time were significantly associated with changes in PROMIS physical function.
CONCLUSIONS: The PVFS scale showed adequate construct validity and responsiveness in a prospective cohort study of patients with VTE, suggesting that it can be incorporated as additional health measurement and outcome parameter in research and clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
Thrombosis research - 221(2023) vom: 15. Jan., Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Steiner, Daniel [VerfasserIn] |
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| Links: |
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| Themen: |
Construct validity |
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| Anmerkungen: |
Date Completed 27.12.2022 Date Revised 12.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.thromres.2022.11.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM349403910 |
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| 100 | 1 | |a Steiner, Daniel |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The post-VTE functional status scale for assessment of functional limitations in patients with venous thromboembolism |b Construct validity and responsiveness in a prospective cohort study |
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| 520 | |a Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: A large proportion of patients experience functional limitations after an acute episode of venous thromboembolism (VTE). Recently, the post-VTE functional status (PVFS) scale was proposed to capture these limitations. We performed a prospective cohort study to validate this scale | ||
| 520 | |a METHODS: The PVFS scale, PROMIS physical function 10a, EQ-5D-5L, and disease-specific quality of life (VEINES-QOL/Sym, PEmb-QoL) were assessed within three weeks of VTE diagnosis and after a median (IQR) follow-up of 13.4 (12.7-15.9) weeks. To evaluate construct validity of the PVFS scale, we determined correlations of PVFS scale with the other health measurements and investigated differences in patients above/below 70 years. Responsiveness was evaluated with a linear regression model, predicting change in PROMIS with change in PVFS scale | ||
| 520 | |a RESULTS: We included 211 patients (median (IQR) age: 55.1 (44.1-67.6) years, 40 % women). Pulmonary embolism was diagnosed in 105 (49.8 %) patients and 62.6 % of events were unprovoked. The PVFS scale correlated with PROMIS physical function (Spearman's rho (r): -0.67 and -0.63, p < 0.001) and EQ-5D-5L index (r = -0.61 and -0.61, p < 0.001) at baseline and follow-up. Furthermore, PVFS correlated moderately to strongly with disease-specific quality of life. Patients >70 years had significantly higher PVFS grades at follow-up (median (IQR): 2 (0-3) vs. 1 (0-2), p = 0.010). Changes in PVFS scale over time were significantly associated with changes in PROMIS physical function | ||
| 520 | |a CONCLUSIONS: The PVFS scale showed adequate construct validity and responsiveness in a prospective cohort study of patients with VTE, suggesting that it can be incorporated as additional health measurement and outcome parameter in research and clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Construct validity | |
| 650 | 4 | |a Functional limitations | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a Responsiveness | |
| 650 | 4 | |a Validation | |
| 650 | 4 | |a Venous thromboembolism | |
| 700 | 1 | |a Nopp, Stephan |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, Benedikt |e verfasserin |4 aut | |
| 700 | 1 | |a Schlager, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Königsbrügge, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Klok, Frederikus A |e verfasserin |4 aut | |
| 700 | 1 | |a Pabinger, Ingrid |e verfasserin |4 aut | |
| 700 | 1 | |a Ay, Cihan |e verfasserin |4 aut | |
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