Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant
Copyright © 2022 by The American Association of Immunologists, Inc..
Although the immunological memory produced by BNT162b2 vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well studied and established, further information using different racial cohorts is necessary to understand the overall immunological response to vaccination. We evaluated memory B and T cell responses to the severe acute respiratory syndrome coronavirus 2 spike protein before and after the third booster using a Japanese cohort. Although the Ab titer against the spike receptor-binding domain (RBD) decreased significantly 8 mo after the second vaccination, the number of memory B cells continued to increase, whereas the number of memory T cells decreased slowly. Memory B and T cells from unvaccinated infected patients showed similar kinetics. After the third vaccination, the Ab titer increased to the level of the second vaccination, and memory B cells increased at significantly higher levels before the booster, whereas memory T cells recovered close to the second vaccination levels. In memory T cells, the frequency of CXCR5+CXCR3+CCR6- circulating follicular Th1 was positively correlated with RBD-specific Ab-secreting B cells. For the response to variant RBDs, although 60-80% of memory B cells could bind to the omicron RBD, their avidity was low, whereas memory T cells show an equal response to the omicron spike. Thus, the persistent presence of memory B and T cells will quickly upregulate Ab production and T cell responses after omicron strain infection, which prevents severe illness and death due to coronavirus disease 2019.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:209 |
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| Enthalten in: |
Journal of immunology (Baltimore, Md. : 1950) - 209(2022), 11 vom: 01. Dez., Seite 2104-2113 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mise-Omata, Setsuko [VerfasserIn] |
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| Links: |
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| Themen: |
BNT162 Vaccine |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 21.04.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.4049/jimmunol.2200525 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349399425 |
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| 245 | 1 | 0 | |a Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant |
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| 520 | |a Copyright © 2022 by The American Association of Immunologists, Inc. | ||
| 520 | |a Although the immunological memory produced by BNT162b2 vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well studied and established, further information using different racial cohorts is necessary to understand the overall immunological response to vaccination. We evaluated memory B and T cell responses to the severe acute respiratory syndrome coronavirus 2 spike protein before and after the third booster using a Japanese cohort. Although the Ab titer against the spike receptor-binding domain (RBD) decreased significantly 8 mo after the second vaccination, the number of memory B cells continued to increase, whereas the number of memory T cells decreased slowly. Memory B and T cells from unvaccinated infected patients showed similar kinetics. After the third vaccination, the Ab titer increased to the level of the second vaccination, and memory B cells increased at significantly higher levels before the booster, whereas memory T cells recovered close to the second vaccination levels. In memory T cells, the frequency of CXCR5+CXCR3+CCR6- circulating follicular Th1 was positively correlated with RBD-specific Ab-secreting B cells. For the response to variant RBDs, although 60-80% of memory B cells could bind to the omicron RBD, their avidity was low, whereas memory T cells show an equal response to the omicron spike. Thus, the persistent presence of memory B and T cells will quickly upregulate Ab production and T cell responses after omicron strain infection, which prevents severe illness and death due to coronavirus disease 2019 | ||
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| 700 | 1 | |a Ikeda, Mari |e verfasserin |4 aut | |
| 700 | 1 | |a Takeshita, Masaru |e verfasserin |4 aut | |
| 700 | 1 | |a Uwamino, Yoshifumi |e verfasserin |4 aut | |
| 700 | 1 | |a Wakui, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Arai, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshifuji, Ayumi |e verfasserin |4 aut | |
| 700 | 1 | |a Murano, Kensaku |e verfasserin |4 aut | |
| 700 | 1 | |a Siomi, Haruhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawara, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ohyagi, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ando, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Saya, Hideyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Murata, Mitsuru |e verfasserin |4 aut | |
| 700 | 1 | |a Fukunaga, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Namkoong, Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Xiuyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yamasaki, Sho |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshimura, Akihiko |e verfasserin |4 aut | |
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