Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease : a EUSTAR database analysis
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVE: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD.
METHODS: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied.
RESULTS: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)].
CONCLUSIONS: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
|---|---|
| Enthalten in: |
Rheumatology (Oxford, England) - 62(2023), 7 vom: 05. Juli, Seite 2483-2491 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Campochiaro, Corrado [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 07.07.2023 Date Revised 18.07.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/rheumatology/keac660 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349262241 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349262241 | ||
| 003 | DE-627 | ||
| 005 | 20231226042213.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/rheumatology/keac660 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1164.xml |
| 035 | |a (DE-627)NLM349262241 | ||
| 035 | |a (NLM)36413079 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Campochiaro, Corrado |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease |b a EUSTAR database analysis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.07.2023 | ||
| 500 | |a Date Revised 18.07.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVE: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD | ||
| 520 | |a METHODS: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied | ||
| 520 | |a RESULTS: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)] | ||
| 520 | |a CONCLUSIONS: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Hoffmann-Vold, Anna-Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Avouac, Jerome |e verfasserin |4 aut | |
| 700 | 1 | |a Henes, Jörg |e verfasserin |4 aut | |
| 700 | 1 | |a de Vries-Bouwstra, Jeska |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Vanessa |e verfasserin |4 aut | |
| 700 | 1 | |a Siegert, Elise |e verfasserin |4 aut | |
| 700 | 1 | |a Airò, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Oksel, Fahrettin |e verfasserin |4 aut | |
| 700 | 1 | |a Pellerito, Raffaele |e verfasserin |4 aut | |
| 700 | 1 | |a Vanthuyne, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Pozzi, Maria Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Inanc, Murat |e verfasserin |4 aut | |
| 700 | 1 | |a Sibilia, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Gabrielli, Armando |e verfasserin |4 aut | |
| 700 | 1 | |a Distler, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Allanore, Yannick |e verfasserin |4 aut | |
| 700 | 0 | |a EUSTAR Collaborators |e verfasserin |4 aut | |
| 700 | 1 | |a Cerinic, Marco Matucci |e investigator |4 oth | |
| 700 | 1 | |a Walker, Ulrich |e investigator |4 oth | |
| 700 | 1 | |a Iannone, Florenzo |e investigator |4 oth | |
| 700 | 1 | |a Becvar, Radim |e investigator |4 oth | |
| 700 | 1 | |a Cuomo, Giovanna |e investigator |4 oth | |
| 700 | 1 | |a Montecucco, C |e investigator |4 oth | |
| 700 | 1 | |a Carreira, Patricia E |e investigator |4 oth | |
| 700 | 1 | |a Iudici, Michele |e investigator |4 oth | |
| 700 | 1 | |a Kucharz, Eugene J |e investigator |4 oth | |
| 700 | 1 | |a Zanatta, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Bancel, Pr Dominique Farge |e investigator |4 oth | |
| 700 | 1 | |a Hesselstrand, Roger |e investigator |4 oth | |
| 700 | 1 | |a Balbir-Gurman, Alexandra |e investigator |4 oth | |
| 700 | 1 | |a Pellerito, Raffaele |e investigator |4 oth | |
| 700 | 1 | |a Bertoldo, Eugenia |e investigator |4 oth | |
| 700 | 1 | |a Damjanov, Nemanja |e investigator |4 oth | |
| 700 | 1 | |a Granollers, Vera Ortiz-Santamaria |e investigator |4 oth | |
| 700 | 1 | |a Heitmann, Stefan |e investigator |4 oth | |
| 700 | 1 | |a Salvador, Maria João |e investigator |4 oth | |
| 700 | 1 | |a Stamenkovic, Bojana |e investigator |4 oth | |
| 700 | 1 | |a Selmi, Carlo Francesco |e investigator |4 oth | |
| 700 | 1 | |a Herrick, Ariane |e investigator |4 oth | |
| 700 | 1 | |a Ller-Ladner, Ulf Mü |e investigator |4 oth | |
| 700 | 1 | |a Engelhart, Merete |e investigator |4 oth | |
| 700 | 1 | |a Riccieri, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Ionescu, Ruxandra Maria |e investigator |4 oth | |
| 700 | 1 | |a Gheorghiu, Ana Maria |e investigator |4 oth | |
| 700 | 1 | |a Sunderkötter, Cord |e investigator |4 oth | |
| 700 | 1 | |a Distler, Jörg |e investigator |4 oth | |
| 700 | 1 | |a Ingegnoli, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Mouthon, Luc |e investigator |4 oth | |
| 700 | 1 | |a Cantatore, Francesco Paolo |e investigator |4 oth | |
| 700 | 1 | |a Ullman, Susanne |e investigator |4 oth | |
| 700 | 1 | |a Wiland, Piotr |e investigator |4 oth | |
| 700 | 1 | |a Vanthuyne, Marie |e investigator |4 oth | |
| 700 | 1 | |a Saar, Petra |e investigator |4 oth | |
| 700 | 1 | |a Herrmann, Kristine |e investigator |4 oth | |
| 700 | 1 | |a De Langhe, Ellen |e investigator |4 oth | |
| 700 | 1 | |a Mayer, Miroslav |e investigator |4 oth | |
| 700 | 1 | |a Yavuz, Sule |e investigator |4 oth | |
| 700 | 1 | |a de Souza Müller, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Zenone, Thierry |e investigator |4 oth | |
| 700 | 1 | |a Vacca, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Solanki, Kamal |e investigator |4 oth | |
| 700 | 1 | |a Rosato, Edoardo |e investigator |4 oth | |
| 700 | 1 | |a Yargucu, Fahrettin Oksel Figen |e investigator |4 oth | |
| 700 | 1 | |a Tanaseanu, Cristina-Mihaela |e investigator |4 oth | |
| 700 | 1 | |a Foti, Rosario |e investigator |4 oth | |
| 700 | 1 | |a Furst, Daniel E |e investigator |4 oth | |
| 700 | 1 | |a Adler, Peter Villiger Sabine |e investigator |4 oth | |
| 700 | 1 | |a Martín, Jorge Juan González |e investigator |4 oth | |
| 700 | 1 | |a Litinsky, Ira |e investigator |4 oth | |
| 700 | 1 | |a Del Galdo, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Seskute, Goda |e investigator |4 oth | |
| 700 | 1 | |a Saketkoo, Lesley Ann |e investigator |4 oth | |
| 700 | 1 | |a Kerzberg, Eduardo |e investigator |4 oth | |
| 700 | 1 | |a Castellví, Ivan |e investigator |4 oth | |
| 700 | 1 | |a Spertini, François |e investigator |4 oth | |
| 700 | 1 | |a Hsu, Vivien M |e investigator |4 oth | |
| 700 | 1 | |a Martin, Thierry |e investigator |4 oth | |
| 700 | 1 | |a Schmeiser, Tim |e investigator |4 oth | |
| 700 | 1 | |a Majewski, Dominik |e investigator |4 oth | |
| 700 | 1 | |a Bernardino, Vera |e investigator |4 oth | |
| 700 | 1 | |a Puttini, Piercarlo Sarzi |e investigator |4 oth | |
| 700 | 1 | |a Moroncini, Gianluca |e investigator |4 oth | |
| 700 | 1 | |a Stork, Jiri |e investigator |4 oth | |
| 700 | 1 | |a Hachulla, Eric |e investigator |4 oth | |
| 700 | 1 | |a de la Pena Lefebvre, Paloma Garcıa |e investigator |4 oth | |
| 700 | 1 | |a Limonta, Massimiliano |e investigator |4 oth | |
| 700 | 1 | |a Sfikakis, Petros |e investigator |4 oth | |
| 700 | 1 | |a Cutolo, Maurizio |e investigator |4 oth | |
| 700 | 1 | |a Ananieva, Lidia P |e investigator |4 oth | |
| 700 | 1 | |a Czirjak, Laszlo |e investigator |4 oth | |
| 700 | 1 | |a Denton, Christopher |e investigator |4 oth | |
| 700 | 1 | |a De Luca, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Dagna, Lorenzo |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Rheumatology (Oxford, England) |d 1999 |g 62(2023), 7 vom: 05. Juli, Seite 2483-2491 |w (DE-627)NLM102581908 |x 1462-0332 |7 nnns |
| 773 | 1 | 8 | |g volume:62 |g year:2023 |g number:7 |g day:05 |g month:07 |g pages:2483-2491 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/rheumatology/keac660 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 62 |j 2023 |e 7 |b 05 |c 07 |h 2483-2491 | ||