Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance
© 2022 The Author(s). Published by S. Karger AG, Basel..
INTRODUCTION: Native T1 mapping values are elevated in acutely injured myocardium. We sought to study whether native T1 values, in the non-infarct related myocardial territories, might differ when supplied by obstructive or nonobstructive coronary arteries.
METHODS: Consecutive patients (N = 60, mean age 59 years) with the first STEMI following primary percutaneous coronary intervention, underwent cardiac magnetic resonance within 5 ± 2 days. A retrospective review of coronary angiography reports classified coronary arteries as infarct-related coronary artery (IRA) and non-IRA. Obstructive coronary artery disease (CAD) was defined as stenosis ≥50%. Native T1 values were presented using a 16-segment AHA model according to the three main coronary territories: left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA).
RESULTS: The cutoff native T1 value for predicting obstructive non-IRA LAD was 1,309 msec with a sensitivity and specificity of 67% and 82%, respectively (AUC 0.76, 95% CI: 0.57-0.95, p = 0.04). The cutoff native T1 value for predicting obstructive non-IRA RCA was 1,302 msec with a sensitivity and specificity of 83% and 55%, respectively (AUC 0.7, 95% CI: 0.52-0.87, p = 0.05). Logistic regression model adjusted for age and infarct size demonstrated that native T1 was an independent predictor for the obstructive non-IRA LAD (OR 4.65; 1.32-26.96, p = 0.05) and RCA (OR 3.70; 1.44-16.35, p = 0.03).
CONCLUSION: Elevated native T1 values are independent predictors of obstructive non-IRA in STEMI patients. These results suggest the presence of concomitant remote myocardial impairment in the non-infarct territories with obstructive CAD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:148 |
|---|---|
| Enthalten in: |
Cardiology - 148(2023), 2 vom: 06., Seite 106-113 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Brodov, Yafim [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiac magnetic resonance |
|---|
| Anmerkungen: |
Date Completed 02.06.2023 Date Revised 18.06.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1159/000528143 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349257159 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349257159 | ||
| 003 | DE-627 | ||
| 005 | 20231226042206.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000528143 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1164.xml |
| 035 | |a (DE-627)NLM349257159 | ||
| 035 | |a (NLM)36412568 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Brodov, Yafim |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.06.2023 | ||
| 500 | |a Date Revised 18.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Author(s). Published by S. Karger AG, Basel. | ||
| 520 | |a INTRODUCTION: Native T1 mapping values are elevated in acutely injured myocardium. We sought to study whether native T1 values, in the non-infarct related myocardial territories, might differ when supplied by obstructive or nonobstructive coronary arteries | ||
| 520 | |a METHODS: Consecutive patients (N = 60, mean age 59 years) with the first STEMI following primary percutaneous coronary intervention, underwent cardiac magnetic resonance within 5 ± 2 days. A retrospective review of coronary angiography reports classified coronary arteries as infarct-related coronary artery (IRA) and non-IRA. Obstructive coronary artery disease (CAD) was defined as stenosis ≥50%. Native T1 values were presented using a 16-segment AHA model according to the three main coronary territories: left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) | ||
| 520 | |a RESULTS: The cutoff native T1 value for predicting obstructive non-IRA LAD was 1,309 msec with a sensitivity and specificity of 67% and 82%, respectively (AUC 0.76, 95% CI: 0.57-0.95, p = 0.04). The cutoff native T1 value for predicting obstructive non-IRA RCA was 1,302 msec with a sensitivity and specificity of 83% and 55%, respectively (AUC 0.7, 95% CI: 0.52-0.87, p = 0.05). Logistic regression model adjusted for age and infarct size demonstrated that native T1 was an independent predictor for the obstructive non-IRA LAD (OR 4.65; 1.32-26.96, p = 0.05) and RCA (OR 3.70; 1.44-16.35, p = 0.03) | ||
| 520 | |a CONCLUSION: Elevated native T1 values are independent predictors of obstructive non-IRA in STEMI patients. These results suggest the presence of concomitant remote myocardial impairment in the non-infarct territories with obstructive CAD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiac magnetic resonance | |
| 650 | 4 | |a Elevated native T1 | |
| 650 | 4 | |a Non-infarcted myocardium | |
| 650 | 4 | |a Obstructive non-infarct-related artery | |
| 650 | 4 | |a STEMI | |
| 700 | 1 | |a Matetzky, Shlomi |e verfasserin |4 aut | |
| 700 | 1 | |a Konen, Eli |e verfasserin |4 aut | |
| 700 | 1 | |a Di Segni, Mattia |e verfasserin |4 aut | |
| 700 | 1 | |a Younis, Anan |e verfasserin |4 aut | |
| 700 | 1 | |a Massalha, Ayas |e verfasserin |4 aut | |
| 700 | 1 | |a Berkovitch, Anat |e verfasserin |4 aut | |
| 700 | 1 | |a Beytelman, Arkadi |e verfasserin |4 aut | |
| 700 | 1 | |a Chernomordik, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Goitein, Orly |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiology |d 1970 |g 148(2023), 2 vom: 06., Seite 106-113 |w (DE-627)NLM000038881 |x 1421-9751 |7 nnns |
| 773 | 1 | 8 | |g volume:148 |g year:2023 |g number:2 |g day:06 |g pages:106-113 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000528143 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 148 |j 2023 |e 2 |b 06 |h 106-113 | ||