Association of polymorphisms in the IL-10 promoter region with Crohn's disease
© 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC..
BACKGROUND: IL-10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL-10 gene and Crohn's disease (CD).
METHODS: In 86 children with CD disease and 142 healthy controls, polymorphisms of three SNPs (rs3790622, rs1800872, and rs1800896) in the IL-10 promoter region were successfully identified. The risk alleles, genotypes, and haplotypes were also analyzed in the CD patient group and the control group. 2 × 2 chi-square test was used to identify whether there is a statistically significant association between CD risk and SNP polymorphisms.
RESULTS: According to the chi-square test results, only the polymorphism of rs1800872 was associated with pediatric CD. T allele in rs1800872 showed a high risk for pediatric CD (Pearson χ2 p = 0.030). TT genotype of rs1800872 was associated with a higher risk of CD in the pediatric population (OR 1.986, 95% CI 1.146-3.442, p = 0.020, TT vs. TG + GG). Finally, a risk haplotype GTT (rs3790622-rs1800872-rs1800896) in IL-10 was found (OR 1.570, 95% CI 1.054-2.341, p = 0.028).
CONCLUSIONS: Our data suggested that T allele, TT genotype, and haplotype GTT in rs1800872 were associated with the susceptibility to pediatric CD in China.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Journal of clinical laboratory analysis - 36(2022), 12 vom: 30. Dez., Seite e24780 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Anna [VerfasserIn] |
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| Links: |
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| Themen: |
130068-27-8 |
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| Anmerkungen: |
Date Completed 20.12.2022 Date Revised 22.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jcla.24780 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349219257 |
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| 500 | |a Date Revised 22.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: IL-10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL-10 gene and Crohn's disease (CD) | ||
| 520 | |a METHODS: In 86 children with CD disease and 142 healthy controls, polymorphisms of three SNPs (rs3790622, rs1800872, and rs1800896) in the IL-10 promoter region were successfully identified. The risk alleles, genotypes, and haplotypes were also analyzed in the CD patient group and the control group. 2 × 2 chi-square test was used to identify whether there is a statistically significant association between CD risk and SNP polymorphisms | ||
| 520 | |a RESULTS: According to the chi-square test results, only the polymorphism of rs1800872 was associated with pediatric CD. T allele in rs1800872 showed a high risk for pediatric CD (Pearson χ2 p = 0.030). TT genotype of rs1800872 was associated with a higher risk of CD in the pediatric population (OR 1.986, 95% CI 1.146-3.442, p = 0.020, TT vs. TG + GG). Finally, a risk haplotype GTT (rs3790622-rs1800872-rs1800896) in IL-10 was found (OR 1.570, 95% CI 1.054-2.341, p = 0.028) | ||
| 520 | |a CONCLUSIONS: Our data suggested that T allele, TT genotype, and haplotype GTT in rs1800872 were associated with the susceptibility to pediatric CD in China | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a IL-10 | |
| 650 | 4 | |a Crohn's disease | |
| 650 | 4 | |a disease risk | |
| 650 | 4 | |a genetic association | |
| 650 | 4 | |a polymorphisms | |
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| 700 | 1 | |a Shang, Shiqiang |e verfasserin |4 aut | |
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