Dynamic changes of hematological indices in oropharyngeal cancer patients treated with radiotherapy
BACKGROUND: Hematological indices assist in predicting clinical outcomes.
OBJECTIVES: To explore changes of hematological indices on oropharynx squamous cell carcinoma (OPSCC) patients received radiotherapy and their association with survival.
MATERIAL AND METHODS: The white blood cell count (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), hemoglobin (Hb), platelet (Plt), albumin (Alb), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at baseline, 1-, 3-, 6- and 12-months follow-up were retrospectively collected. The trajectory of indices was described. A linear model with random effects was to describe indices' changing rate and trend. Univariable Cox analysis was to assess the correlation between indices and survival.
RESULTS: Of the 85 patients, WBC and ALC dropped during acute phase and gradually recovered, while NLR and PLR increased during acute phase and subsequently declined (all p < .01). Higher absolute value of nutritional indices (Alb and Hb) was associated with better prognosis (p < .05). In contrast, patients with higher absolute value or upward trend of inflammatory indices (ANC, Plt, NLR and PLR) had worse survival (p < .05).
CONCLUSIONS AND SIGNIFICANCE: The short- and long-term changes of indices differed in OPSCC patients received radiotherapy, and absolute values and dynamic changes of indices had the potential to be prognostic factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:142 |
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| Enthalten in: |
Acta oto-laryngologica - 142(2022), 9-12 vom: 18. Sept., Seite 705-711 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
Hematological indices |
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| Anmerkungen: |
Date Completed 04.01.2023 Date Revised 11.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00016489.2022.2140823 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349109419 |
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| 500 | |a Date Revised 11.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Hematological indices assist in predicting clinical outcomes | ||
| 520 | |a OBJECTIVES: To explore changes of hematological indices on oropharynx squamous cell carcinoma (OPSCC) patients received radiotherapy and their association with survival | ||
| 520 | |a MATERIAL AND METHODS: The white blood cell count (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), hemoglobin (Hb), platelet (Plt), albumin (Alb), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at baseline, 1-, 3-, 6- and 12-months follow-up were retrospectively collected. The trajectory of indices was described. A linear model with random effects was to describe indices' changing rate and trend. Univariable Cox analysis was to assess the correlation between indices and survival | ||
| 520 | |a RESULTS: Of the 85 patients, WBC and ALC dropped during acute phase and gradually recovered, while NLR and PLR increased during acute phase and subsequently declined (all p < .01). Higher absolute value of nutritional indices (Alb and Hb) was associated with better prognosis (p < .05). In contrast, patients with higher absolute value or upward trend of inflammatory indices (ANC, Plt, NLR and PLR) had worse survival (p < .05) | ||
| 520 | |a CONCLUSIONS AND SIGNIFICANCE: The short- and long-term changes of indices differed in OPSCC patients received radiotherapy, and absolute values and dynamic changes of indices had the potential to be prognostic factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hematological indices | |
| 650 | 4 | |a NLR | |
| 650 | 4 | |a PLR | |
| 650 | 4 | |a oropharyngeal cancer | |
| 650 | 4 | |a radiotherapy | |
| 700 | 1 | |a Cheng, Danni |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Yaxin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Shaohui |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Yufang |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Minzi |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Wendu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Junhong |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Jianjun |e verfasserin |4 aut | |
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