Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals : the Egyptian example
© 2022. The Author(s)..
In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accounting for the false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs, while unveiling the proportion of infections remaining undiagnosed despite routine testing. We relied on longitudinal data, including results of routine RT-PCR tests, collected within three Egyptian quarantine hospitals. We estimated an incidence rate (per 100 person-day, PD) of 1.05 (95% CrI 0.58-1.65) at Hospital 1, 1.92 (95% CrI 0.93-3.28) at Hospital 2 and 7.62 (95% CrI 3.47-13.70) at Hospital 3. We found that the risk for an HCW to be infected during a working shift lay within the range of risk levels previously documented in standard healthcare settings for Hospitals 1-2, whereas it was > threefold higher for Hospital 3. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Scientific reports - 12(2022), 1 vom: 17. Nov., Seite 19773 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jijón, Sofía [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 10.01.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-022-23428-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349100829 |
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| 520 | |a © 2022. The Author(s). | ||
| 520 | |a In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accounting for the false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs, while unveiling the proportion of infections remaining undiagnosed despite routine testing. We relied on longitudinal data, including results of routine RT-PCR tests, collected within three Egyptian quarantine hospitals. We estimated an incidence rate (per 100 person-day, PD) of 1.05 (95% CrI 0.58-1.65) at Hospital 1, 1.92 (95% CrI 0.93-3.28) at Hospital 2 and 7.62 (95% CrI 3.47-13.70) at Hospital 3. We found that the risk for an HCW to be infected during a working shift lay within the range of risk levels previously documented in standard healthcare settings for Hospitals 1-2, whereas it was > threefold higher for Hospital 3. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Al Shafie, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan, Essam |e verfasserin |4 aut | |
| 700 | 0 | |a EMAE-MESuRS working group on nosocomial SARS-CoV-2 modeling |e verfasserin |4 aut | |
| 700 | 1 | |a Temime, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Jean, Kévin |e verfasserin |4 aut | |
| 700 | 1 | |a El-Kassas, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Duval, Audrey |e investigator |4 oth | |
| 700 | 1 | |a Hamzi, Kenza |e investigator |4 oth | |
| 700 | 1 | |a Hendrickx, Niels |e investigator |4 oth | |
| 700 | 1 | |a Oodally, Ajmal |e investigator |4 oth | |
| 700 | 1 | |a Opatowski, Lulla |e investigator |4 oth | |
| 700 | 1 | |a Shirreff, George |e investigator |4 oth | |
| 700 | 1 | |a Smith, David R M |e investigator |4 oth | |
| 700 | 1 | |a Tamandjou, Cynthia |e investigator |4 oth | |
| 700 | 1 | |a Jijón, Sofía |e investigator |4 oth | |
| 700 | 1 | |a Temime, Laura |e investigator |4 oth | |
| 700 | 1 | |a Jean, Kévin |e investigator |4 oth | |
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