Are Staphylococcus aureus Carrier Types Evidence of Population Heterogeneity?
© Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2022. This work is written by (a) US Government employee(s) and is in the public domain in the US..
Asymptomatic colonization by Staphylococcus aureus is a precursor for infection, so identifying the mode and source of transmission which leads to colonization could help in targeting interventions. Longitudinal studies have shown that some people are persistently colonized for years, while others seem to carry S. aureus for weeks or less, and conventional wisdom attributes this disparity to an underlying risk factor in the persistently colonized. We analyze published data with mathematical models of acquisition and carriage to compare this hypothesis with alternatives. The null model assumed a homogeneous population and still produced highly variable colonization durations (mean = 101.7 weeks; 5th percentile, 5.2 weeks; 95th percentile, 304.7 weeks). Simulations showed that this inherent variability, combined with censoring in longitudinal cohort studies, is sufficient to produce the appearance of "persistent carriers," "intermittent carriers," and "noncarriers" in data. Our estimates for colonization duration exhibited sensitivity to the assumption that false-positive test results can occur despite being rare, but our model-based approach simultaneously estimates specificity and sensitivity along with epidemiologic parameters. Our results show it is plausible that S. aureus colonizes people indiscriminately, and improved understanding of the types of exposures which result in colonization is essential.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:192 |
|---|---|
| Enthalten in: |
American journal of epidemiology - 192(2023), 3 vom: 24. Feb., Seite 455-466 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Beams, Alexander [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bacterial infection |
|---|
| Anmerkungen: |
Date Completed 07.03.2023 Date Revised 29.07.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/aje/kwac201 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM349099014 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM349099014 | ||
| 003 | DE-627 | ||
| 005 | 20231226041821.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/aje/kwac201 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1163.xml |
| 035 | |a (DE-627)NLM349099014 | ||
| 035 | |a (NLM)36396618 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Beams, Alexander |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Are Staphylococcus aureus Carrier Types Evidence of Population Heterogeneity? |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.03.2023 | ||
| 500 | |a Date Revised 29.07.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2022. This work is written by (a) US Government employee(s) and is in the public domain in the US. | ||
| 520 | |a Asymptomatic colonization by Staphylococcus aureus is a precursor for infection, so identifying the mode and source of transmission which leads to colonization could help in targeting interventions. Longitudinal studies have shown that some people are persistently colonized for years, while others seem to carry S. aureus for weeks or less, and conventional wisdom attributes this disparity to an underlying risk factor in the persistently colonized. We analyze published data with mathematical models of acquisition and carriage to compare this hypothesis with alternatives. The null model assumed a homogeneous population and still produced highly variable colonization durations (mean = 101.7 weeks; 5th percentile, 5.2 weeks; 95th percentile, 304.7 weeks). Simulations showed that this inherent variability, combined with censoring in longitudinal cohort studies, is sufficient to produce the appearance of "persistent carriers," "intermittent carriers," and "noncarriers" in data. Our estimates for colonization duration exhibited sensitivity to the assumption that false-positive test results can occur despite being rare, but our model-based approach simultaneously estimates specificity and sensitivity along with epidemiologic parameters. Our results show it is plausible that S. aureus colonizes people indiscriminately, and improved understanding of the types of exposures which result in colonization is essential | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Staphylococcus aureus | |
| 650 | 4 | |a bacterial infection | |
| 650 | 4 | |a carriage duration | |
| 650 | 4 | |a carriage types | |
| 650 | 4 | |a colonization | |
| 650 | 4 | |a longitudinal data | |
| 650 | 4 | |a mathematical modeling | |
| 650 | 4 | |a maximum likelihood | |
| 700 | 1 | |a Keegan, Lindsay T |e verfasserin |4 aut | |
| 700 | 1 | |a Adler, Frederick R |e verfasserin |4 aut | |
| 700 | 1 | |a Samore, Matthew H |e verfasserin |4 aut | |
| 700 | 1 | |a Khader, Karim |e verfasserin |4 aut | |
| 700 | 1 | |a Toth, Damon J A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of epidemiology |d 1965 |g 192(2023), 3 vom: 24. Feb., Seite 455-466 |w (DE-627)NLM000012327 |x 1476-6256 |7 nnns |
| 773 | 1 | 8 | |g volume:192 |g year:2023 |g number:3 |g day:24 |g month:02 |g pages:455-466 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/aje/kwac201 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 192 |j 2023 |e 3 |b 24 |c 02 |h 455-466 | ||