Demographics, pattern of practice and clinical outcomes in rectal squamous cell carcinoma
© 2022 Association of Coloproctology of Great Britain and Ireland..
AIM: The aim of this study was to describe the baseline clinical features, treatment patterns and outcomes in rectal squamous cell carcinoma (SCC).
METHOD: This is a retrospective study of patients with rectal SCC treated at the Princess Margaret Cancer Centre (Toronto, Canada) between 1 January 1995 and 31 December 2020. Clinical factors associated with locoregional failure (LRF), distant metastases (DM), disease-free survival (DFS) and overall survival (OS), such as age, sex, HIV status, T-category, nodal status, grade and primary treatment, were investigated with univariate analysis (UVA).
RESULTS: Twenty nine patients with rectal SCC were analysed with a median follow-up of 7.4 years (range 0.3-20.4 years). The median age at diagnosis was 52 years, with the majority presenting with clinical T3 disease or higher (n = 21, 72%) and positive regional lymph nodes (n = 16, 55%), while more than quarter of patients (28%) had metastatic disease. Definitive chemoradiation was the treatment modality of choice in more than half of all cases (n = 17, 59%) with a response rate of 100%. The 10-year cumulative incidence of LRF and DM was, respectively, 12% (95% CI 1.8%-32.9%) and 31% (95% CI: 12.0%-52.6%). The 5- and 10-year OS was 82% (95% CI 66.1%-100%). UVA revealed a trend towards an association of male gender (hazard ratio = 4.65, 95% CI 0.9%-24.1; p = 0.067) and primary surgical treatment (hazard ratio = 0.76, 95% CI 0.09-6.34; p = 0.061) with DFS.
CONCLUSION: Definitive chemoradiation is an effective and preferred treatment for rectal SCC allowing for sphincter preservation with complete clinical response observed in all patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 25(2023), 4 vom: 25. Apr., Seite 608-615 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Id Said, Badr [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 01.05.2023 Date Revised 05.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/codi.16417 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM349083045 |
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| 245 | 1 | 0 | |a Demographics, pattern of practice and clinical outcomes in rectal squamous cell carcinoma |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Association of Coloproctology of Great Britain and Ireland. | ||
| 520 | |a AIM: The aim of this study was to describe the baseline clinical features, treatment patterns and outcomes in rectal squamous cell carcinoma (SCC) | ||
| 520 | |a METHOD: This is a retrospective study of patients with rectal SCC treated at the Princess Margaret Cancer Centre (Toronto, Canada) between 1 January 1995 and 31 December 2020. Clinical factors associated with locoregional failure (LRF), distant metastases (DM), disease-free survival (DFS) and overall survival (OS), such as age, sex, HIV status, T-category, nodal status, grade and primary treatment, were investigated with univariate analysis (UVA) | ||
| 520 | |a RESULTS: Twenty nine patients with rectal SCC were analysed with a median follow-up of 7.4 years (range 0.3-20.4 years). The median age at diagnosis was 52 years, with the majority presenting with clinical T3 disease or higher (n = 21, 72%) and positive regional lymph nodes (n = 16, 55%), while more than quarter of patients (28%) had metastatic disease. Definitive chemoradiation was the treatment modality of choice in more than half of all cases (n = 17, 59%) with a response rate of 100%. The 10-year cumulative incidence of LRF and DM was, respectively, 12% (95% CI 1.8%-32.9%) and 31% (95% CI: 12.0%-52.6%). The 5- and 10-year OS was 82% (95% CI 66.1%-100%). UVA revealed a trend towards an association of male gender (hazard ratio = 4.65, 95% CI 0.9%-24.1; p = 0.067) and primary surgical treatment (hazard ratio = 0.76, 95% CI 0.09-6.34; p = 0.061) with DFS | ||
| 520 | |a CONCLUSION: Definitive chemoradiation is an effective and preferred treatment for rectal SCC allowing for sphincter preservation with complete clinical response observed in all patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a radiotherapy | |
| 650 | 4 | |a rectal cancer | |
| 650 | 4 | |a squamous cell carcinoma | |
| 700 | 1 | |a Buchan, David |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zijin |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, John |e verfasserin |4 aut | |
| 700 | 1 | |a Hosni, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Brierley, James D |e verfasserin |4 aut | |
| 700 | 1 | |a Chadi, Sami |e verfasserin |4 aut | |
| 700 | 1 | |a Grant, Robert C |e verfasserin |4 aut | |
| 700 | 1 | |a Kalimuthu, Sangeetha |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhihui Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Lukovic, Jelena |e verfasserin |4 aut | |
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